Evidence map›Paper›PMID 39698728›Full record

ArticleQuantitative imaging in medicine and surgery2024

The value of quantitative muscle ultrasound in monitoring muscle and fascia inflammatory activity in juvenile dermatomyositis patients.

Luyu Liu, Xinning Wang, Yedi Wang, Mingxue Wang, Ya Ma, Jianguo Li

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Article in Quantitative imaging in medicine and surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Luyu Liu *Department of Ultrasound, Children's Hospital Affiliated with Capital Institute of Pediatrics, Beijing, China.
Xinning Wang *Department of Rheumatology, Children's Hospital Affiliated with Capital Institute of Pediatrics, Beijing, China.
Yedi WangDepartment of Ultrasound, Children's Hospital Affiliated with Capital Institute of Pediatrics, Beijing, China.
Mingxue WangDepartment of Ultrasound, Children's Hospital Affiliated with Capital Institute of Pediatrics, Beijing, China.
Ya MaDepartment of Ultrasound, Children's Hospital Affiliated with Capital Institute of Pediatrics, Beijing, China.
Jianguo LiDepartment of Rheumatology, Children's Hospital Affiliated with Capital Institute of Pediatrics, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Currently, the activity of juvenile dermatomyositis (JDM) is mainly assessed based on clinical manifestations, creatine kinase (CK) level, and magnetic resonance imaging (MRI), but certain limitations arise in these approaches for children. Thus, this cross-sectional study aimed to explore the value of ultrasound in evaluating muscle inflammation via the dynamic analysis of muscle ultrasound characteristics in children with active or stable JDM. Methods: The data of a group of children who were diagnosed with JDM and admitted to the Rheumatology and Immunology Department of the Capital Pediatric Research Institute Children's Hospital between June 2022 and November 2023, and a normal control group were collected. The clinical, ultrasound, and laboratory data of the children with active and stable JDM were collected and compared with those of a normal control group. Muscle thickness (MT), fascia thickness (FT), muscle echo intensity (EI), muscle microvascular flow imaging (MVFI) distribution, and the blood flow resistance index (RI) were measured via ultrasound for the comparative analysis. A Spearman correlation analysis was conducted to assess the correlation between the ultrasound parameters in the JDM patients, and muscle scores and laboratory indicators of disease activity. Receiver operating characteristic (ROC) curves were generated for the ultrasound parameters. Five active JDM children were dynamically followed up. Results: The data of 26 children with active JDM, 29 with stable JDM, and 31 normal control children were collected. The patients with active JDM had significantly greater EI (median 68.9 Conclusions: EI, FT, and MVFI distribution can be used to assess the activity status of individuals with JDM, and are correlated with clinical activity indices. EI may be abnormal even in children with a stable clinical condition, which suggests that ultrasound may more accurately reflect muscle status. Children with long-term unresolved fasciitis may be at risk of developing calcification.

Indexed as

disease activityJuvenile dermatomyositis (JDM)quantitative muscle ultrasound

Identifiers

PMID39698728
PMCPMC11651955

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