Evidence map›Paper›PMID 39698360›Full record

ArticleKidney international reports2024

Steroid-Resistant Nephrotic Syndrome Is Associated With a Unique Genetic Profile in a Highly Admixed Pediatric Population.

Andreia Watanabe, Precil Diego Miranda de Menezes Neves, Kelly Nunes, Antonio Marcondes Lerario, Elieser Hitoshi Watanabe, Frederico Moraes Ferreira, Denise Maria Avancini Costa Malheiros, Amanda de Moraes Narcizo, Mara Sanches Guaragna, Stanley de Almeida Araujo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Update on APOL1 and chronic kidney diseases in children.Pediatric nephrology (Berlin, Germany) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andreia WatanabeDepartment of Pediatrics, University of São Paulo School of Medicine, São Paulo, Brazil.
Precil Diego Miranda de Menezes NevesDivision of Molecular Medicine, University of São Paulo School of Medicine, São Paulo, Brazil.
Kelly NunesDepartment of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Antonio Marcondes LerarioDivision of Endocrinology, University of Michigan, Ann Arbor, Michigan, USA.
Elieser Hitoshi WatanabeDivision of Molecular Medicine, University of São Paulo School of Medicine, São Paulo, Brazil.
Frederico Moraes FerreiraDepartment of Pathology, University of São Paulo School of Medicine, São Paulo, Brazil.
Denise Maria Avancini Costa MalheirosDepartment of Pathology, University of São Paulo School of Medicine, São Paulo, Brazil.
Amanda de Moraes NarcizoLaboratório de Sequenciamento em Larga Escala (SELA), University of São Paulo School of Medicine, São Paulo, Brazil.
Mara Sanches GuaragnaCenter for Molecular Biology and Genetic Engineering, State University of Campinas, Campinas, Brazil.
Stanley de Almeida AraujoDivision of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Thais Medeiros CruzDivision of Pediatric Nephrology, Federal University of Rio Grande do Norte, Natal, Brazil.
Jussara Soares FontesFederal University of São João Del Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, Brazil.
Vera Maria Santoro BelangeroDepartment of Pediatrics, State University of Campinas, Campinas, Brazil.
Maria Helena VaisbichDepartment of Pediatrics, University of São Paulo School of Medicine, São Paulo, Brazil.
Friedhelm HildebrandtDivision of Pediatric Nephrology, Boston Children's Hospital, Boston, Massachusetts, USA.
Matthew Gordon SampsonDivision of Pediatric Nephrology, Boston Children's Hospital, Boston, Massachusetts, USA.
Luiz Fernando OnuchicDivision of Molecular Medicine, University of São Paulo School of Medicine, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The profile of genetic and nongenetic factors associated with progression to kidney failure (KF) in steroid-resistant nephrotic syndrome (SRNS) is largely unknown in admixed populations. Methods: A total of 101 pediatric patients with primary SRNS were genetically assessed targeting Mendelian causes and Results: Focal segmental glomerulosclerosis (FSGS) was diagnosed in 54% of patients whereas familial disease was reported by 13%. The global genetic ancestry was 65% European, 22% African, 10.5% Native American, and 2% East-Asian, while 96% of cases presented with the first 3 components. Conclusion: Mendelian variants and

Indexed as

APOL1childrenfocal segmental glomerulosclerosisgenetic ancestrymonogenic chronic kidney diseasesteroid-resistant nephrotic syndrome

Identifiers

PMID39698360
PMCPMC11652071

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.