Evidence map›Paper›PMID 39698160›Full record

ArticleRoyal Society open science2024

Identification of a novel nuclease activity in human DDX49 helicase.

Ashley J Parkes, Sabesan Anandavijayan, Anna Lou-Hing, Olivia Downs, Tom Killelea, Louise Martin, Fiorela Kapllanaj, Edward L Bolt

Abstract read
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In one paragraph

Article in Royal Society open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ashley J ParkesSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0003-1678-6039
Sabesan AnandavijayanSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Anna Lou-HingSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0009-0007-0543-8529
Olivia DownsSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-0487-9783
Tom KilleleaSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Louise MartinSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Fiorela KapllanajSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Edward L BoltSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-5656-7706

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human DDX49 is an emerging target in cancer progression and retroviral diseases through its essential roles in nucleolar RNA processing. Here, we identify nuclease activity of human DDX49, which requires active site aspartate residues within a conserved region of metazoan DDX49s that is absent from yeast and archaeal DDX49 homologues. We provide evidence that DDX49 nuclease activity is facilitated by its helicase activity. Using CRISPR-Cas9 genetic editing, we show that a heterozygous (

Indexed as

activityDDX49helicasehumannovelnuclease

Identifiers

PMID39698160
PMCPMC11651898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.