Evidence map›Paper›PMID 39698148›Full record

ArticleFrontiers in human neuroscience2024

Alterations in large-scale resting-state network nodes following transcranial focused ultrasound of deep brain structures.

Stephanie M Gorka, Jagan Jimmy, Katherine Koning, K Luan Phan, Natalie Rotstein, Bianca Hoang-Dang, Sabrina Halavi, Norman Spivak, Martin M Monti, Nicco Reggente and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephanie M GorkaDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Jagan JimmyDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Katherine KoningDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
K Luan PhanDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Natalie RotsteinDepartment of Psychiatry and Biobehavioral Sciences, The University of California, Los Angeles, Los Angeles, CA, United States.
Bianca Hoang-DangDepartment of Psychiatry and Biobehavioral Sciences, The University of California, Los Angeles, Los Angeles, CA, United States.
Sabrina HalaviDepartment of Psychiatry and Biobehavioral Sciences, The University of California, Los Angeles, Los Angeles, CA, United States.
Norman SpivakDepartment of Psychiatry and Biobehavioral Sciences, The University of California, Los Angeles, Los Angeles, CA, United States.
Martin M MontiDepartment of Psychology, The University of California, Los Angeles, Los Angeles, CA, United States.
Nicco ReggenteInstitute for Advanced Consciousness Studies, Santa Monica, CA, United States.
Susan Y BookheimerDepartment of Psychiatry and Biobehavioral Sciences, The University of California, Los Angeles, Los Angeles, CA, United States.
Taylor P KuhnDepartment of Psychiatry and Biobehavioral Sciences, The University of California, Los Angeles, Los Angeles, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Low-intensity transcranial focused ultrasound (tFUS) is a brain stimulation approach that holds promise for the treatment of brain-based disorders. Studies in humans have shown that tFUS can successfully modulate perfusion in focal sonication targets, including the amygdala; however, limited research has explored how tFUS impacts large-scale neural networks. Objective: The aim of the current study was to address this gap and examine changes in resting-state connectivity between large-scale network nodes using a randomized, double-blind, within-subjects crossover study design. Methods: Healthy adults ( Results: tFUS altered resting-state functional connectivity (rsFC) within and between rs-network nodes. Pre-to-post sonication of the right amygdala modulated connectivity within nodes of the salience network (SAN) and between nodes of the SAN and the default mode network (DMN) and frontoparietal network (FRP). A decrease in SAN to FPN connectivity was specific to the amygdala target. Pre-to-post sonication of the left ErC modulated connectivity between the dorsal attention network (DAN) and FPN and DMN. An increase in DAN to DMN connectivity was specific to the ErC target. Conclusion: These preliminary findings may suggest that tFUS induces neuroplastic changes beyond the immediate sonication target. Additional studies are needed to determine the long-term stability of these effects.

Indexed as

amygdaladefault mode networkentorhinal cortexresting-state functional connectivitysalience network (SN)transcranial focused ultrasound

Identifiers

PMID39698148
PMCPMC11652661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.