Evidence map›Paper›PMID 39698098›Full record

ArticleHeliyon2024

Phytol and bilimbi phytocompounds induce thermogenic adipocyte differentiation: An in vitro study on potential anti-obesity effects.

Farah Md Fauzi, Mohamad Faiz Hamzah, Muhd Zulkarnain Mahmud, Azimah Amanah, Mohd Hasnan Mohd Noor, Zafarina Zainuddin, Wai Kwan Lau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Farah Md FauziMalaysian Institute of Pharmaceuticals & Nutraceuticals, National Institutes of Biotechnology Malaysia, Block 5A, Halaman Bukit Gambir, 11700, Gelugor, Penang, Malaysia.
Mohamad Faiz HamzahMalaysian Institute of Pharmaceuticals & Nutraceuticals, National Institutes of Biotechnology Malaysia, Block 5A, Halaman Bukit Gambir, 11700, Gelugor, Penang, Malaysia.
Muhd Zulkarnain MahmudMalaysian Institute of Pharmaceuticals & Nutraceuticals, National Institutes of Biotechnology Malaysia, Block 5A, Halaman Bukit Gambir, 11700, Gelugor, Penang, Malaysia.
Azimah AmanahMalaysian Institute of Pharmaceuticals & Nutraceuticals, National Institutes of Biotechnology Malaysia, Block 5A, Halaman Bukit Gambir, 11700, Gelugor, Penang, Malaysia.
Mohd Hasnan Mohd NoorMalaysian Institute of Pharmaceuticals & Nutraceuticals, National Institutes of Biotechnology Malaysia, Block 5A, Halaman Bukit Gambir, 11700, Gelugor, Penang, Malaysia.
Zafarina ZainuddinAnalytical Biochemistry Research Centre, Universiti Sains Malaysia, 11800, USM, Penang, Malaysia.
Wai Kwan LauMalaysian Institute of Pharmaceuticals & Nutraceuticals, National Institutes of Biotechnology Malaysia, Block 5A, Halaman Bukit Gambir, 11700, Gelugor, Penang, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a major health concern associated to diabetes, cardiovascular disease, and cancer. Brown adipocytes, which specialise in thermogenesis, offer a potential therapeutic target for obesity prevention and related conditions. This study builds on previous findings of the browning activity of Averrhoa bilimbi hexane fractions and aims to elucidate the underlying mechanisms in vitro. Squalene and phytol, key phytocompounds from bilimbi leaf extract and fractions, were assessed for their ability to induce thermogenic adipocyte using 3T3-L1 preadipocytes and C2C12 myoblasts in vitro models. The result shows that bilimbi fractions F7, F8, and F9, along with squalene and phytol, effectively induced thermogenic adipocyte differentiation. This was evidenced by the upregulation of key markers, including

Indexed as

Averrhoa bilimbiBrown adipocytesObesityPhytolPrdm16SqualeneThermogenic adipocytesUcp1White adipocytes

Identifiers

PMID39698098
PMCPMC11652845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.