Evidence map›Paper›PMID 39698091›Full record

ArticleHeliyon2024

Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes.

Siyuan Wang, Huan Jiang, Moran Hu, Yingyun Gong, Hongwen Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Local host fish-Food and waterborne parasitology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siyuan WangDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.
Huan JiangDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.
Moran HuDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.
Yingyun GongDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.
Hongwen ZhouDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sphingomyelin is an important member of the sphingolipid family and was first reported more than a century ago. It has been demonstrated that sphingomyelin plays a crucial role in compositing cell membranes and signaling pathways. Despite extensive functional studies on the sphingolipid metabolism pathway genes, one intriguing question remains: how does the emergence of these genes during evolution correlate with the acquisition of new functions in different species? By employing an evolutionary conservation analysis, the sequence of occurrence of biological processes during evolutionary history can be elucidated. Here we summarize and analyze the conservation status of the genes involved in sphingomyelin metabolism.

Indexed as

Ceramidede novo synthesis pathwayInterspecies conservation statusSalvage synthesis pathwaySphingomyelin

Identifiers

PMID39698091
PMCPMC11652929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.