Evidence map›Paper›PMID 39698047›Full record

ArticleFrontiers in surgery2024

Predictors of mortality at 3 months in patients with skull base tumor resections in a low-income setting.

Mestet Yibeltal Shiferaw, Abat Sahlu Baleh, Abel Gizaw, Tsegazeab Laeke Teklemariam, Abenezer Tirsit Aklilu, Atalel Fentahun Awedew, Denekew Tenaw Anley, Bereket Hailu Mekuria, Ermias Fikiru Yesuf, Mengistu Ayele Yigzaw and 7 more

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Article in Frontiers in surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

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17 authors.

Mestet Yibeltal ShiferawDepartment of Surgery, Neurosurgery Unit, Debre Tabor University, Debre Tabor, Ethiopia.
Abat Sahlu BalehDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.
Abel GizawDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.
Tsegazeab Laeke TeklemariamDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.
Abenezer Tirsit AkliluDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.
Atalel Fentahun AwedewDepartment of Surgery, Debre Tabor University, Debre Tabor, Ethiopia.
Denekew Tenaw AnleyDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Bereket Hailu MekuriaDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.
Ermias Fikiru YesufDepartment of Surgery, Neurosurgery Unit, Debre Birhan University, Debre Birhan, Ethiopia.
Mengistu Ayele YigzawDepartment of Surgery, Neurosurgery Unit, Hawassa University, Hawassa, Ethiopia.
Henok Teshome MollaDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.
Mekides Muse AwanoDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.
Alemu Adise MldieDepartment of Surgery, Neurosurgery Unit, Jimma University, Jimma, Ethiopia.
Endeshaw Chekole AbebeDepartment of Clinical Health Science - Precision Health, University of South Australia, Adelaide, SA, Australia.
Nebyou HailuDepartment of Surgery, Neurosurgery Unit, Hawassa University, Hawassa, Ethiopia.
Sura DanielDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.
Dejen Teke GebrewahdDepartment of Surgery, Neurosurgery Unit, Addis Ababa University, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Globally, skull base tumors are among the most challenging tumors to treat and are known for their significant morbidity and mortality. Hence, this study aimed to identify robust associated factors that contribute to mortality of patients following surgical resection for a variety of skull base tumors at the 3-month follow-up period. This in turn helps devise an evidence-based meticulous treatment strategy and baseline input for quality improvement work. Methodology: A retrospective cohort study of patients undergoing skull base tumor resection was conducted at two large-volume neurosurgery centers in Ethiopia. The categorical variables were expressed in frequencies and percentages. Normal distribution of continuous data was checked by histogram and the Shapiro-Wilk test. Median with interquartile range (IQR) was calculated for skewed data, while mean with standard deviation (SD) was used for normally distributed data. Odds ratio and adjusted odds ratio (AOR) were used to express the result of univariate and multivariate binary logistic analyses, respectively. A Result: The study involved 266 patients. Of this, women accounted for 63.5% of patients. The median age of patients was 37 (±IQR = 17) years while the median size of the tumor in this study was 4.9 (±IQR 1.5) cm. The mean duration of symptoms at time of presentation was 17.3 (±SD = 11.1) months. Meningioma, pituitary adenoma, and craniopharyngioma contributed to 68.4%, 19.2%, and 9% of the skull-based tumors, respectively. Mortality following skull base tumor resection was 21.1%. On multivariable binary logistic regression analysis, intraoperative iatrogenic vascular insult (AOR = 28.76, 95% CI: 6.12-135.08, Conclusion: Mortality from skull base tumor resection remains high in our setting. Holistic pre-operative surgical planning, meticulous intraoperative execution of procedures, and post-operative dedicated follow-up of patients in a neurointensive care unit alongside quality improvement works on identified risks of mortality are strongly recommended to improve patient outcomes. The urgent need for setup improvement and further training of neurosurgeons is also underscored.

Indexed as

Ethiopiameningiomamortalitypituitary adenomaresectionskull base tumors

Identifiers

PMID39698047
PMCPMC11653179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.