Evidence map›Paper›PMID 39697631›Full record

ReviewExtracellular vesicles and circulating nucleic acids2024

Hitting the target: cell signaling pathways modulation by extracellular vesicles.

Giada Cerrotti, Sandra Buratta, Raffaella Latella, Eleonora Calzoni, Gaia Cusumano, Agnese Bertoldi, Serena Porcellati, Carla Emiliani, Lorena Urbanelli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Extracellular vesicles and circulating nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giada CerrottiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.
Sandra BurattaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.
Raffaella LatellaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.
Eleonora CalzoniDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.
Gaia CusumanoDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.
Agnese BertoldiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.
Serena PorcellatiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.
Carla EmilianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.
Lorena UrbanelliDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released outside the cell. EVs have drawn attention not only for their role in cell waste disposal, but also as additional tools for cell-to-cell communication. Their complex contents include not only lipids, but also proteins, nucleic acids (RNA, DNA), and metabolites. A large part of these molecules are involved in mediating or influencing signal transduction in target cells. In multicellular organisms, EVs have been suggested to modulate signals in cells localized either in the neighboring tissue or in distant regions of the body by interacting with the cell surface or by entering the cells via endocytosis or membrane fusion. Most of the EV-modulated cell signaling pathways have drawn considerable attention because they affect morphogenetic signaling pathways, as well as pathways activated by cytokines and growth factors. Therefore, they are implicated in relevant biological processes, such as embryonic development, cancer initiation and spreading, tissue differentiation and repair, and immune response. Furthermore, it has recently emerged that multicellular organisms interact with and receive signals through EVs released by their microbiota as well as by edible plants. This review reports studies investigating EV-mediated signaling in target mammalian cells, with a focus on key pathways for organism development, organ homeostasis, cell differentiation and immune response.

Indexed as

EGFRexosomesExtracellular vesiclesHedgehogHippomicrovesiclesNotchTGF-βWnt

Identifiers

PMID39697631
PMCPMC11648414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.