Evidence map›Paper›PMID 39696843›Full record

ArticleDiabetes, obesity & metabolism2025

Association between time in tight range and incident diabetic retinopathy in adults with type 2 diabetes.

Yaxin Wang, Jingyi Lu, Jiamin Yu, Jiaying Ni, Ming Wang, Wei Lu, Wei Zhu, Jingyi Guo, Yuqian Bao, Jian Zhou

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PubMed Full text at PMC Publisher
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Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

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0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yaxin WangDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Jingyi LuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Jiamin YuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Jiaying NiDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Ming WangDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Wei LuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Wei ZhuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Jingyi GuoClinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuqian BaoDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.ORCID 0000-0002-4754-3470
Jian ZhouDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.ORCID 0000-0002-1534-2279

Funding

National Key Clinical Specialty Z155080000004Program of Shanghai Academic Research Leader 22XD1402300Shanghai Key Discipline of Public Health Grants Award GWVI-11.1-20Shanghai Key Discipline of Public Health Grants Award GWVI-11.1-22Shanghai Oriental Talent Program (Youth Project) NAShanghai Research Center for Endocrine and Metabolic Diseases 2022ZZ01002
6 · The paper itself

Abstract

aimsTime spent in the glucose range of 70-180 mg/dL (TIR) has become entrenched as a key measure of glycaemic control, which was linked to diabetes-related outcomes in previous studies. However, there has been a recent debate about whether to instead emphasize time in the target range of 70-140 mg/dL (time in tight range, TITR). We aimed to assess the association between TITR and incident diabetic retinopathy in adults with type 2 diabetes. MATERIALS AND

methodsThis is a dynamic cohort study conducted at a tertiary hospital. 2518 adults with type 2 diabetes and without diabetic retinopathy at baseline were finally included. TITR was obtained from continuous glucose monitoring data at baseline. Cox proportional hazard regression analysis was performed to assess the relationships of TITR with the risk of incident diabetic retinopathy.

resultsDuring a mean follow-up period of 5.43 years, 646 patients developed retinopathy. The multivariable-adjusted hazard ratios (HRs) for incident retinopathy across descending TITR quartiles (Q4: >58% [reference], Q3: 38% ~ 57%, Q2: 19% ~ 37%, and Q1: <19%) were 1.00, 1.47 (95%CI 1.16, 1.87), 1.52 (95%CI 1.20, 1.93) and 1.93 (95%CI 1.53, 2.43), respectively. For per 10% decrease in TITR, the risk of diabetic retinopathy was increased by 9% (HR = 1.09, 95%CI 1.06, 1.13) after full adjustment for covariates. In the TIR >70% subgroup, the significant association between TIR, as a continuous variable and the risk of incident retinopathy disappeared, whereas TITR remained significantly associated with the outcome. Similar results were observed in the TIR >80% and TIR >90% subgroups.

conclusionsTITR is inversely associated with the incidence of diabetic retinopathy in adults with type 2 diabetes. Among adults with well-controlled TIR (70% or higher), TITR may provide added value regarding glucose control.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2Diabetic RetinopathyGlycemic ControlAdultAgedBlood Glucose Self-MonitoringCohort StudiesFemaleGlycated HemoglobinHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRisk FactorsBlood GlucoseGlycated Hemoglobincontinuous glucose monitoringdiabetic retinopathytime in tight rangetype 2 diabetes mellitus

Identifiers

PMID39696843
PMCPMC11802404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.