Evidence map›Paper›PMID 39696807›Full record

ArticleAging cell2025

Age-Dependent Bi-Phasic Dynamics of Ly49

Saranya Srinivasan, Shruti Mishra, Kenneth Ka-Ho Fan, Liwen Wang, John Im, Courtney Segura, Neelam Mukherjee, Gang Huang, Manjeet Rao, Chaoyu Ma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. CD8+ Regulatory T Cells.Annual review of immunology · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saranya SrinivasanDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Shruti MishraDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Kenneth Ka-Ho FanDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Liwen WangDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
John ImDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Courtney SeguraDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Neelam MukherjeeDepartment of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Gang HuangDepartment of Cell Systems and Anatomy, Greehey Children's Cancer Research Institute, San Antonio, Texas, USA.
Manjeet RaoDepartment of Cell Systems and Anatomy, Greehey Children's Cancer Research Institute, San Antonio, Texas, USA.
Chaoyu MaDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Nu ZhangDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.ORCID 0000-0001-9695-210X

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR002645 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2018 to 2022
$20.4M
A Novel Regulator of Antitumor Immunity and ImmunotherapyR01CA288321 · NCI · GEORGE WASHINGTON UNIVERSITY · PI YANFEN HU, Rong Li · 2024 to 2026
$2.0M
Mechanistic study of TGF-beta-dependent control of gut-resident memory T cellsR01AI125701 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHANG, NU · 2016 to 2020
$2.0M
Lymphoid residency of Tcf-1+ CD8+ T cells during tumor vaccine responsesR01AI177345 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Nu Zhang · 2024 to 2026
$1.3M
BLRD VA I01 BX005955NCATS NIH HHS UL1 TR002645NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA288321NIAID NIH HHS R01 AI125701NIAID NIH HHS R01 AI177345NIH HHS AI125701NIH HHS AI177345NIH HHS CA288321VA I01BX005955
6 · The paper itself

Abstract

Aging is tightly associated with reduced immune protection but increased risk of autoimmunity and inflammatory conditions. Regulatory T cells are one of the key cells to maintaining immune homeostasis. The age-dependent changes in CD4

Indexed as

AgingCD8-Positive T-LymphocytesT-Lymphocytes, RegulatoryAdultAnimalsFemaleHumansMaleMiceMice, Inbred C57BLagingCD8 TregHeliosNKG2D

Identifiers

PMID39696807
PMCPMC11984669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.