Evidence map›Paper›PMID 39696774›Full record

ArticleBJPsych open2024

The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust.

Ashwin V Venkataraman, Pooja Kandangwa, Roos Lemmen, Rutvi Savla, Mazda Beigi, Devon Hammond, Daniel Harwood, Justin Sauer, Latha Velayudhan, Clive Ballard and 3 more

Abstract read
In one paragraph

Article in BJPsych open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ashwin V VenkataramanCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.ORCID https://orcid.org/0000-0001-7977-1948
Pooja KandangwaCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Roos LemmenCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Rutvi SavlaCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Mazda BeigiSouth London and Maudsley NHS Foundation Trust, London, UK.
Devon HammondSouth London and Maudsley NHS Foundation Trust, London, UK.
Daniel HarwoodSouth London and Maudsley NHS Foundation Trust, London, UK.
Justin SauerSouth London and Maudsley NHS Foundation Trust, London, UK.
Latha VelayudhanCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Clive BallardCollege of Medicine and Health, University of Exeter, UK.
Anna-Katharine BremCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.ORCID https://orcid.org/0000-0003-0295-6834
Chris KalafatisCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Dag AarslandCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.ORCID https://orcid.org/0000-0001-6314-216X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe novel South London and Maudsley Brain Health Clinic (SLaM BHC) leverages advances in remote consultations and biomarkers to provide a timely, cost-efficient and accurate diagnosis in mild cognitive impairment (MCI).

aimsTo describe the organisation, patient cohort and acceptability of the remote diagnostic and interventional procedures.

methodWe describe the recruitment, consultation set-up, the clinical and biomarker programme, and the two online group interventions for cognitive wellbeing and lifestyle change. We evaluate the acceptability of the remote consultations, lumbar puncture, saliva genotyping, and remote cognitive and functional assessments.

resultsWe present the results of the first 68 (mean age 73, 55% female, 43% minoritised ethnicity) of 146 people who enrolled for full remote clinical, cognitive, genetic, cerebrospinal fluid and neuroimaging phenotyping. A total of 86% were very satisfied/satisfied with the remote service. In all, 67% consented to lumbar puncture, and 95% of those were very satisfied, all having no significant complications. A total of 93% found taking saliva genotyping very easy/easy, and 93% found the cognitive assessments instructions clear. In all, 98% were satisfied with the Cognitive Wellbeing Group, and 90% of goals were achieved in the Lifestyle Intervention Group.

conclusionsThe SLaM BHC provides a highly acceptable and safe clinical model for remote assessments and lumbar punctures in a representative, ethnically diverse population. This allows early and accurate diagnosis of Alzheimer's disease, differentiation from other MCI causes and targets modifiable risk factors. This is crucial for future disease modification, ensuring equitable access to research, and provides precise, timely and cost-efficient diagnoses in UK mental health services.

Indexed as

biomarkersdementiamild cognitive impairmentold age psychiatryRemote brain health clinic

Identifiers

PMID39696774
PMCPMC11733455

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.