ArticleEuropean journal of medical research2024
Neutrophil-related indicators as potential peripheral blood biomarkers for the diagnosis of neurosyphilis: a cross-sectional study.
Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Demographic and laboratory characteristics of neurosyphilis: a retrospective cohort study from a tertiary dermatosis hospital.BMC infectious diseases · 2026Article
- Clinical presentation of neurosyphilis - a single-center retrospective data analysis.Neurological research and practice · 2026Article
- Research progress on the mechanisms of neurosyphilis' impact on cognitive function, early identification, and prevention strategies.Frontiers in neurology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurosyphilis (NS) is the most serious complication elicited by the invasion of Treponema pallidum (T. pallidum) into the central nervous system. Identifying the neuro-invasion of T. pallidum as early as possible is important. Looking for indicators with good performance and convenient to operate is in great demand for the diagnosis of NS.
methodsA cross-sectional study was conducted on 428 human immunodeficiency virus (HIV)-negative syphilis patients who underwent therapy in Shanghai Skin Disease Hospital from April 2022 to June 2023. The syphilis patients were further grouped into non-neurosyphilis (NNS), asymptomatic neurosyphilis (ANS) and symptomatic syphilis (SNS). Laboratory examination results of these patients were analyzed.
resultsSignificantly elevated neutrophil CD64 (nCD64) index and neutrophil to lymphocyte ratio (NLR) were observed in ANS and SNS patients compared with those of NNS patients. nCD64 index and NLR were strongly correlated with serum and cerebrospinal fluid (CSF) TRUST titer, CSF WBC and CSF protein levels in NS patients. nCD64 index and NLR were independent factors influencing NS, especially ANS. Logistic regression models based on nCD64 index, NLR and serum TRUST titer exhibited better diagnostic performances to the currently used markers in NS diagnosis. Particularly, for NS patients with negative CSF TRUST, diagnostic performance of the combined nCD64 and NLR was obviously superior to CSF protein and CSF WBC.
conclusionsNeutrophil-related indicators-nCD64 index and NLR have potential application value in the diagnosis of NS, especially for the CSF TRUST negative patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.