Evidence map›Paper›PMID 39696663›Full record

ArticleEuropean journal of medical research2024

Clinical significance of serum Helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina.

Haizhen Jia, Huajun Fan, Jinhe Zhao, Jun Peng, Yunhong Pan, Hongyan Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haizhen Jia *Cardiovascular Department, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430064, Hubei, People's Republic of China.
Huajun Fan *Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, People's Republic of China.
Jinhe ZhaoCardiovascular Department, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430064, Hubei, People's Republic of China.
Jun PengCardiovascular Department, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430064, Hubei, People's Republic of China.
Yunhong PanCardiovascular Department, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430064, Hubei, People's Republic of China.
Hongyan PengDepartment of Ultrasound Imaging, Taikang Tongji (Wuhan) Hospital, No. 322 North Sixin Road, Hanyang District, Wuhan, 430050, Hubei, People's Republic of China. PengHongyan19@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe investigated the clinical significance of serum Helicobacter pylori cytotoxin-associated gene A (CagA) antibody levels in 768 patients with unstable angina (UA).

methodsSerum CagA levels were measured using ELISA. Demographic data, serum biomarkers, and SYNTAX scores were collected. Patients were followed up for 1 year for major adverse cardiac events (MACE).

resultsCagA-positive UA patients had higher total cholesterol and hsCRP levels, and SYNTAX scores. CagA levels correlated positively with TC, hsCRP, and SYNTAX scores. Kaplan-Meier analysis showed shorter MACE-free survival in CagA-positive UA patients. CagA levels predicted MACE occurrence within 1 year, along with SYNTAX scores.

conclusionsSerum H. pylori CagA antibody positivity is associated with worse prognosis in UA patients. CagA levels correlate with lipid metabolism and inflammatory markers.

Indexed as

Angina, UnstableAntigens, BacterialBacterial ProteinsHelicobacter pyloriAgedAntibodies, BacterialBiomarkersClinical RelevanceFemaleHelicobacter InfectionsHumansMaleMiddle AgedPrognosisAntibodies, BacterialAntigens, BacterialBacterial ProteinsBiomarkerscagA protein, Helicobacter pyloriCytotoxin-associated gene AHelicobacter pyloriSYNTAXUnstable angina

Identifiers

PMID39696663
PMCPMC11657787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.