Evidence map›Paper›PMID 39696342›Full record

ArticleJournal of nanobiotechnology2024

An antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction.

Ziyi Gu, Xueliang Liu, Zhen Qi, Zhou Fang, Yiting Jiang, Yuting Huang, Yongyi Wang, Lianming Wu, Yu Yang

Erratum issuedAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Dual ROS modulation by MnOTheranostics · 2026
    Article
  11. Review
  12. Comprehensive Plasma Oxylipin Profiling Reveals a Pro-Inflammatory Eicosanoid Signature and Diagnostic Biomarker Panel in Dilated Cardiomyopathy.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  13. Biomedical Applications of Nanozymes: An Enzymology Perspective.Angewandte Chemie (International ed. in English) · 2025
    Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ziyi Gu *Institute of Molecular Medicine (IMM), department of Cardiovascular Surgery, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xueliang Liu *Institute of Molecular Medicine (IMM), department of Cardiovascular Surgery, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhen QiDepartment of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhou FangInstitute of Molecular Medicine (IMM), department of Cardiovascular Surgery, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yiting JiangInstitute of Molecular Medicine (IMM), department of Cardiovascular Surgery, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yuting HuangInstitute of Molecular Medicine (IMM), department of Cardiovascular Surgery, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yongyi WangInstitute of Molecular Medicine (IMM), department of Cardiovascular Surgery, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China. yongyiwang77@163.com.
Lianming WuDepartment of Radiology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, 200240, China. wlmssmu@126.com.
Yu YangInstitute of Molecular Medicine (IMM), department of Cardiovascular Surgery, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China. yuyang@shsmu.edu.cn.

Funding

"Clinic Plus" Outstanding Project from Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, and Innovative research team of high-level local universities in Shanghai 2021ZYB009"Clinic Plus" Outstanding Project from Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, and Innovative research team of high-level local universities in Shanghai 2023ZYB006National Key Research and Development Program of China 2022YFA1206500National Key Research and Development Program of China 2023YFA0915400National Natural Science Foundation of China 22107065National Natural Science Foundation of China 22277072National Natural Science Foundation of China 82271608the Fundamental Research Funds for the Central Universities 2020JCPT02
6 · The paper itself

Abstract

The excessive release of reactive oxygen species (ROS) after myocardial infarction (MI) disrupts the natural healing process, leading to cardiac fibrosis and compromising patient prognosis. However, the clinical application of many antioxidant drugs for MI treatment is hindered by their poor antioxidant efficacy and inability to specifically target the heart. Here we developed a tannic acid-modified MnO

Indexed as

AntioxidantsFibrosisManganese CompoundsMyocardial InfarctionMyocardiumOxidesReactive Oxygen SpeciesSuperoxide DismutaseTanninsAnimalsCatalaseHumansMaleMiceMice, Inbred C57BLNanoparticlesAntioxidantsCatalaseManganese Compoundsmanganese dioxideOxidesReactive Oxygen SpeciesSuperoxide DismutaseTanninsCardiac fibrosisHeart-targetedMyoardial infarctionNanozyme

Identifiers

PMID39696342
PMCPMC11656654

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.