ArticleBMC public health2024
Investigation of the relationship between lead exposure in heavy metals mixtures and the prevalence of stroke: a cross-sectional study.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Fenugreek Seed Powder Attenuates Lead-Induced Hepatic Injury and Renal Dysfunction in Male Mice Co-Exposed to Escalating Lead Doses.Current issues in molecular biology · 2026Article
- Sleep variability and risk of type 2 diabetes mellitus: Mediating role of social participation in a national longitudinal cohort study.Medicine · 2026Article
- Lead exposure increases the risk of retinal vein occlusion: a population-based analysis and investigation of PRICKLE4/PLCXD1-mediated endothelial cell mechanisms.Frontiers in public health · 2026Article
- Observational
- Heavy metal mixtures exposure and breast cancer risk: synergistic effects with SHBG identified by mediation and moderation models.BMC public health · 2025Article
- The impact of multidisciplinary accompaniment interventions on negative emotions and caregiving ability of family members of ostomy patients: exploring the mediating effect of social isolation.Frontiers in psychology · 2025Article
- Commentary: Association between metallic implants and stroke in US adults from NHANES 2015-2023 a cross-sectional study.Frontiers in aging neuroscience · 2025Article
- Impact of exposure of particulate matters on stroke risk: exploring the influence of physical activity among middle-aged and older adults in China.Frontiers in public health · 2025Article
- Environmental determinants of cerebral haemorrhage in older adults: behavioural pathways and population health implications.Frontiers in public health · 2025Review
- Relationship between air pollution exposure and insulin resistance in Chinese middle-aged and older populations: evidence from Chinese cohort.Frontiers in public health · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe adverse effects of environmental toxic metal exposure on human health are well-documented. However, the specific influence of heavy metal exposure on stroke prevalence remains underexplored.
methodsThis study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018 to investigate the association between blood metal concentrations and the incidence of stroke. Four analytical approaches-logistic regression, Restricted Cubic Splines (RCS), Weighted Quantile Sum regression (WQS), and Bayesian Kernel Machine Regression (BKMR)-were employed to assess the relationship, with a mediation analysis conducted to explore the role of inflammatory markers in Pb exposure-induced stroke.
resultsAmong the 9,399 participants in this project, 421 (4.4%) were diagnosed with stroke. After adjusting for covariates, a multivariable logistic regression model identified a positive association between the logarithmic concentration of Pb and the incidence of stroke. Besides, the analysis conducted using both WQS and BKMR methodologies found a consistent positive association between the composite exposure to heavy metals and the frequency of stroke cases, with Pb emerging as the predominant factor in this relationship. An evident saturation phenomenon was noted in the correlation between lead exposure and the risk of stroke. Additionally, the interplay between Pb exposure and stroke manifestation was found to be partially mediated by inflammatory markers, which were responsible for 6.9% of the observed effect (95%CI:0.01, 0.24, P = 0.03).
conclusionThese findings indicate a notable contribution of Pb exposure to stroke risk, highlighting inflammation as a significant intermediary mechanism in the Pb exposure-stroke association.
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