ArticleBMC psychiatry2024
Biological links between psychological factors and adolescent depression: childhood trauma, rumination, and resilience.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Structural equation modeling of the effect of childhood trauma on premenstrual syndrome: the mediating role of rumination in adolescent girls.Scientific reports · 2026Article
- Metabolic profiling in major depressive disorder with high psychological resilience: changes in amino acid and carbohydrate metabolism.BMC psychiatry · 2026Article
- Augmented reality-based fine arts education experiences and adolescents' perceived reduction in depressive symptoms: a self-report study of associations with psychological resilience, rumination, and emotional regulation.Frontiers in psychiatry · 2026Article
- Depression in Chinese adolescents: prevalence, symptoms, risk factors, affected brain, diagnosis, and interventions.Frontiers in psychology · 2026Review
- Associations of childhood trauma with clinical features and inflammatory cytokines in adolescents with first-episode and recurrent major depressive disorder.Frontiers in immunology · 2026Article
- Impact of Adverse Childhood Experiences and Rumination on Metacognition in Chinese Urban Adolescents with Major Depressive Disorder.Psychology research and behavior management · 2026Article
- Associations between suicidal ideation and childhood maltreatment as well as inflammatory cytokines in adolescents with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2025Article
- The effect of perceived parental rejection on depression in high school students: the chain mediating role of rumination and alexithymia.Frontiers in psychology · 2025Article
- The mediating role of family intimacy: negative emotions and resilience in adolescents with depressive disorders.Frontiers in psychiatry · 2025Article
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6 authors.
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Abstract
backgroundThe psychosocial factors play an important role in the development of depression in adolescents. we used metabolomics techniques to explore the links among childhood trauma, rumination, resilience, and adolescent depression.
methodsWe selected 57 adolescent depression patients and 53 healthy adolescents. The Childhood Trauma Questionnaire (CTQ), Hamilton Depression Scale (HAMD), Resilience Scale (CD-RISC), and Redundant Thinking Response Scale (RRS) were employed for the purpose of psychological assessment. The patients were regrouped according to their scores using the 27% high-low grouping method. Blood specimens were collected from all adolescents and metabolic data were obtained using LC-MS.
resultsWe found no statistically significant difference between the groups in terms of age, gender, and body mass index (BMI). HAMD, CTQ, and RRS scores were significantly higher in the adolescent depression group (MDD) than in the adolescent healthy control group (HC), and CD-RISP scores were significantly lower than in the HC group (P < 0.001). There were significant differences between the low childhood trauma group (LCT) and high childhood trauma group (HCT), the low rumination group (LRR) and high rumination group (HRR), and the low resilience group (LPR) and high resilience group (HPR) (P < 0.001). RRS, CTQ and HAMD scores were positively correlated, RRS and CTQ scores were positively correlated, CD-RIS was negatively correlated with HAMD, RRS and CTQ scores (P < 0.01). More importantly, we found that DHEAS and LPA (22:6) were identified as significant differential metabolites in both the depressed and normal groups, as well as in the high and low childhood trauma groups. N-Acetyl-L-aspartic acid and DHEAS were identified as significant differential metabolites in both the depressed and normal groups, as well as in the high and low childhood rumination groups. Pseudouridine and LPA(22:6) were identified as significant differential metabolites in both the depressed and normal groups, as well as in the high and low childhood resilience groups.
conclusionPsychological factors (childhood trauma, rumination, resilience) are biologically linked to the development of depression in adolescents. The impact of rumination on adolescent depression may be associated with DHEA. The impact of childhood trauma and resilience on adolescent depression may be associated with LPA (22:6).
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