ArticleBMC psychiatry2024
Association between cognitive function, antioxidants, and clinical variables in Chinese patients with schizophrenia.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Long-term benzodiazepine use is associated with poorer cognitive function in schizophrenia: findings from the SALT-C cohort.BMC psychiatry · 2026Observational
- The relationship between cognitive function and inflammatory-nutritional status in schizophrenia: cognitive impairment is inversely related to PNI and CALLY indices.BMC psychiatry · 2026Article
- Alteration pattern of serum albumin levels in schizophrenia from first episode through remission to relapse: a longitudinal study.Translational psychiatry · 2026Article
- Effects of serum hypersensitive C-reactive protein and BMI on cognitive dysfunction in first-episode and drug-naive patients with major depressive disorder.BMC psychiatry · 2026Article
- Prevalence and influencing factors associated with the risk of malnutrition among long-term inpatients with schizophrenia in China.Frontiers in psychiatry · 2026Article
- Efficacy of Huoxue Tongqiao Decoction combined with aniracetam in treating post-stroke cognitive impairment in elderly patients with ischemic stroke and its effects on serum levels of superoxide dismutase, glutathione peroxidase and nitric oxide.Pakistan journal of medical sciences · 2026Article
- Interrelationships among oxidative stress, niacin response, cognition, and symptoms in chronic schizophrenia: a case-control study.BMC psychiatry · 2025Observational
- Association between EEG microstate and cognitive function in depressed patients with and without suicidal ideation.BMC psychiatry · 2025Observational
- Cognitive impairment and its influencing factors in patients with stable schizophrenia on regular medication: a real-world clinical study.BMC psychiatry · 2025Article
- Relationship between renal function and cognitive impairment in patients with stable schizophrenia: a multicenter cross-sectional study.BMC psychiatry · 2025Article
- Transcriptional Patterns of Nodal Entropy Abnormalities in Major Depressive Disorder Patients with and without Suicidal Ideation.Research (Washington, D.C.) · 2025Article
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Authors and funding
13 authors.
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Abstract
objectiveCognitive dysfunction is a prevalent and intricate manifestation of schizophrenia (SCZ) that may be associated with distinct clinical factors and the presence of antioxidants, which relationship is unclear. The study aimed to investigate cognitive function and its influencing factors in Chinese patients with SCZ.
methodsA group of 133 patients with SCZ and 120 healthy controls (HCs) were recruited. The MATRICS Consensus Cognitive Battery (MCCB) was utilized to evaluate cognitive ability, and the Positive and Negative Syndrome Scale (PANSS) was used to assess clinical symptoms. Levels of plasma superoxide dismutase (SOD), serum albumin (ALB) and uric acid (UA) were assessed.
resultsCompared with HCs, patients with SCZ exhibited lower cognitive performance as indicated by MCCB scores, including the dimensions of speed of processing, attention/vigilance, working memory, verbal learning, and visual learning. In the SCZ group, total PANSS scores were negatively associated with all MCCB dimensions (all p < 0.05), except for the attention/vigilance score. The PANSS-negative and PANSS-cognitive subscores were negatively associated with speed of processing, verbal learning, and visual learning scores (all p < 0.05). The PANSS-excited subscores showed a negative correlation with working memory and visual learning scores (all p < 0.05). ALB levels significantly decreased, and their UA and SOD levels were notably elevated compared to HCs (all p < 0.05). ALB levels and PANSS-negative factors were correlated with to speed of processing, working memory, and visual learning dimensions. SOD levels were independent contributors to the attention/vigilance dimension.
conclusionThe cognitive function was decreased in SCZ. The degree of cognitive impairment was closely related to ALB, SOD levels and negative clinical symptoms.
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