Evidence map›Paper›PMID 39696119›Full record

ArticleBMC psychiatry2024

Aberrant amplitude of low-frequency fluctuation and functional connectivity in children with different subtypes of ADHD: a resting-state fNIRS study.

Qinwei Liu, Wenjing Liao, Li Yang, Longfei Cao, Ningning Liu, Yongxue Gu, Shaohua Wang, Xiaobin Xu, Huafen Wang

Abstract read
In one paragraph

Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qinwei Liu *The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Wenjing Liao *Department of Psychology, Children's Hospital, Zhejiang University School of Medicine, National Children's Regional Medical Center, National Clinical Research Center for Child Health, Hangzhou, 310052, P.R. China.
Li YangThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Longfei CaoCentre for Cognition and Brain disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, 311121, P.R. China.
Ningning LiuPeking University Sixth Hospital, Institute of Mental Health, Beijing, 100191, China.
Yongxue GuWeifang People's Hospital, Weifang, 261041, China.
Shaohua WangAffiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, P.R. China.
Xiaobin XuThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. xuxiaobin@zju.edu.cn.
Huafen WangThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. 2185015@zju.edu.cn.

Funding

Medical and Health Science and Technology Project of Zhejiang Province 2020361674
6 · The paper itself

Abstract

backgroundAttention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with different subtypes of pathogenesis. Insufficient research on the subtypes of ADHD has limited the effectiveness of therapeutic methods.

methodsThis study used resting-state functional near-infrared spectroscopy (fNIRS) to record hemodynamic signals in 34 children with ADHD-combined subtype (ADHD-C), 52 children with ADHD-inattentive subtype (ADHD-I), and 24 healthy controls (HCs). The amplitude of low-frequency fluctuation (ALFF) and the functional connectivity (FC) analysis were conducted for all subjects.

resultsCompared with HCs, the ADHD group exhibited significantly increased ALFF and decreased FC. The ADHD-C group showed significantly higher ALFF in partial brain regions and significantly lower FC between multiple brain regions than participants with ADHD-I. The male group displayed a significant increase in ALFF in some brain regions, while no significant difference was found in FC when compared to the female group.

conclusionsThis study provides evidence to support the subtype classification of ADHD-I and ADHD-C, and the combined analysis of ALFF and FC has the potential to be a promising biomarker for the diagnosis of ADHD.

Indexed as

Attention Deficit Disorder with HyperactivitySpectroscopy, Near-InfraredAdolescentBrainCase-Control StudiesChildConnectomeFemaleHumansMaleAmplitude of low-frequency fluctuationFunctional connectivityFunctional near-infrared spectroscopySubtypes of ADHD

Identifiers

PMID39696119
PMCPMC11658069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.