Evidence map›Paper›PMID 39696024›Full record

ArticleBMC neurology2024

A case report about focal status epilepticus as first presentation in Alzheimer's disease: finding the culprit.

Astrid Devulder, Greet Vanderlinden, Evy Cleeren, Valerie Goovaerts, Tom Theys, Koen Van Laere, Wim Van Paesschen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Astrid DevulderLaboratory for Epilepsy Research, KU Leuven, Belgium. astrid.devulder@uzleuven.be.
Greet VanderlindenNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Belgium.
Evy CleerenDepartment of Neurology, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Valerie GoovaertsDepartment of Neurology, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
Tom TheysResearch Group Experimental Neurosurgery and Neuroanatomy, KU Leuven, Belgium.
Koen Van LaereNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Belgium.
Wim Van PaesschenLaboratory for Epilepsy Research, KU Leuven, Belgium.

Funding

Internal Funds KU Leuven (Bijzonder Onderzoeksfonds BOF) C24/18/097
6 · The paper itself

Abstract

backgroundNeuronal hyperexcitability has been proposed to play a key role in Alzheimer's disease (AD). Understanding the relation between this enhanced excitability and AD pathology could provide a window for therapeutic interventions. However epileptiform activity is often subclinical, hidden on scalp EEG and very challenging to assess with current diagnostic modalities. CASE PRESENTATION: A woman in her sixties presented with acute confusion. Despite a normal scalp electroencephalogram (EEG), magnetic resonance imaging (MRI) showed cytotoxic edema of the right mesial temporal lobe and hippocampal hypermetabolism was present on ([

conclusionThis case highlights the significant role of neuronal hyperexcitability in early AD pathogenesis and how shared mechanisms between AD and epilepsy can complicate clinical management.

Indexed as

Alzheimer DiseaseElectroencephalographyPositron-Emission TomographyStatus EpilepticusFemaleHippocampusHumansMagnetic Resonance ImagingMiddle AgedAlzheimer’s diseaseCase reportHippocampal atrophyTau pathologyTemporal lobe epilepsy

Identifiers

PMID39696024
PMCPMC11654376

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.