ArticleClinical diabetes and endocrinology2024
Impact of maternal thyroid dysfunction on fetal and maternal outcomes in pregnancy: a prospective cohort study.
Article in Clinical diabetes and endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of hypothyroidism among pregnant women and associated feto-maternal outcomes in India: Systematic review and meta-analysis.The Indian journal of medical research · 2026Pooled it
- Article
- Evaluating the Two-Step TSH Screening Protocol for Congenital Hypothyroidism: Prevalence and Diagnostic Accuracy in Ninh Binh, Vietnam.Journal of the ASEAN Federation of Endocrine Societies · 2026Article
- Thyroid-Stimulating Hormone and Free Thyroxine Levels at Labor Admission: Associations with Obstetric and Neonatal Outcomes in Term Pregnancies.Diagnostics (Basel, Switzerland) · 2026Article
- Development and validation of an interpretable machine learning model for predicting incident gestational hypothyroidism using clinical laboratory markers.Frontiers in medicine · 2026Article
- Clinical Characteristics and Pregnancy Outcomes of Thyrotoxicosis During Pregnancy: A Retrospective Observational Study.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Increased first-trimester CA125 levels associated with the development of preeclampsia.Journal of translational medicine · 2025Article
- Effect of Autoimmune Thyroid Disease on Pregnancy Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Pregnancy-associated thyroid disorders: the role of genetic, epigenetic, and oxidative stress factors.Reviews in endocrine & metabolic disorders · 2025Review
- Neonates at Risk: Understanding the Impact of High-Risk Pregnancies on Neonatal Health.Medicina (Kaunas, Lithuania) · 2025Review
- Predictive value of thyroid hormone levels for postpartum hemorrhage in hypothyroidism-complicated pregnancy.Frontiers in endocrinology · 2025Article
- Impact of Hypothyroidism in Pregnancy on Feto-Maternal Outcomes: A Prospective Observational Study.Cureus · 2024Article
- Effects of Autoimmune Thyroiditis on Pregnancy Outcomes: Analysis of the Nationwide Inpatient Sample, 2016-2020.Reproductive medicine and biologyArticle
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Authors and funding
7 authors.
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Abstract
backgroundThyroid dysfunction in pregnancy can adversely impact maternal and fetal outcomes. However, the association between thyroid status and specific adverse outcomes needs clarity, especially in understudied regions.
objectiveThis prospective cohort study aimed to illuminate the multifaceted associations between maternal thyroid dysfunction and feto-maternal outcomes in Gujarat, India.
methodsThis hospital-based cohort study recruited and monitored 500 euthyroid, 250 hypothyroid, and 150 hyperthyroid pregnant women until delivery. Maternal thyroid status was determined by serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels. Adverse fetal outcomes included preterm birth, neonatal intensive care unit (NICU) admission, respiratory issues, and low APGAR scores. Maternal outcomes included preeclampsia, haemorrhage, hypertension, postpartum thyroiditis, and thromboembolism. Relative risks quantified associations between thyroid dysfunction and outcomes.
resultsCompared to euthyroid women, hypothyroid women had a higher RR for preterm birth (RR 1.8, 95% CI 1.1-3.0), low APGAR score (RR 2.5, 95% CI 1.5-4.1), preeclampsia (RR 3.0, 95% CI 1.9-4.8), postpartum haemorrhage (RR 1.6, 95% CI 1.2-2.1), and venous thromboembolism (RR 3.1, 95% CI 1.7-5.7). Hyperthyroid women had over twice the risk of low APGAR score (RR 1.8, 95% CI 0.9-3.5), neonatal hypoglycemia (RR 1.5, 95% CI 0.5-4.3), respiratory distress (RR 1.4, 95% CI 0.7-2.8), and postpartum thyroiditis (RR 2.3, 95% CI 1.1-4.8).
conclusionMaternal thyroid dysfunction escalates risks for adverse fetal and maternal outcomes. Thyroid monitoring and management during pregnancy are critical to mitigate complications.
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