Evidence map›Paper›PMID 39695846›Full record

ArticleEuropean journal of medical research2024

The diagnostic and prognostic value of heparin-binding protein in cerebrospinal fluid for patients with intracranial infections.

Yutao Ye, Jianwei Chen, Jianqing Xu, Qing Luo, Peng Fu, Feng Zhao, Zikun Huang

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Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yutao Ye *Department of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Zhengjie, Nanchang, 330006, Jiangxi, China.
Jianwei Chen *Department of Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jianqing XuDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Zhengjie, Nanchang, 330006, Jiangxi, China.
Qing LuoDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Zhengjie, Nanchang, 330006, Jiangxi, China.
Peng FuDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Zhengjie, Nanchang, 330006, Jiangxi, China.
Feng ZhaoDepartment of Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. zficu@163.com.
Zikun HuangDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Zhengjie, Nanchang, 330006, Jiangxi, China. ndyfy03677@ncu.edu.cn.

Funding

Jiangxi Administration of Traditional Chinese Medicine 2022A356Jiangxi Department of Education GJJ2200104Outstanding Youth Fund of Jiangxi Natural Science Foundation 20212ACB216006the High-end Talents Project of Jiangxi "Double Thousand Plan" Science and Technology Innovation jxsq2019201094the National Natural Science Foundation of China 82360322the Province Natural Science Foundation of Jiangxi Province 20232ACB206027the Province Natural Science Foundation of Jiangxi Province 20242BAB20388
6 · The paper itself

Abstract

backgroundThis study aims to evaluate the diagnostic and prognostic value of heparin-binding protein (HBP) in cerebrospinal fluid (CSF) for patients with intracranial infections.

methodsThis study included 211 subjects, of whom 138 were diagnosed with intracranial infections, 20 were patients with non-infectious inflammatory encephalopathies, and 53 controls who were eventually excluded from intracranial infections and inflammatory encephalopathies. The levels of HBP and procalcitonin (PCT) in CSF were detected in the subjects, and the diagnostic value of CSF HBP and PCT for intracranial infections was assessed using the receiver operating characteristic (ROC) curves. In addition, CSF HBP levels in patients with intracranial infections were dynamically monitored on days 1, 5, and 9 post-treatment.

resultsThe levels of HBP in CSF were significantly higher in the infection group compared to both the non-infectious inflammatory encephalopathy group and the control group. The area under the ROC curve (AUC) for CSF HBP in diagnosing intracranial infection was 0.916 (95% CI 0.870-0.950), which was significantly higher than that of CSF PCT (AUC: 0.543, 95% CI 0.474-0.612). Furthermore, the combination of CSF HBP and white blood cell (WBC) counts exhibited a significantly higher AUC of 0.957 (95% CI 0.920-0.980) compared to HBP alone (P<0.05). The AUC for the combination of CSF HBP and PCT was 0.920 (95% CI 0.875-0.953). In addition, elevated concentrations of CSF HBP were observed in patients with bacterial infections and positive microbiological results (P<0.05). Following treatment, CSF HBP levels in patients with intracranial infections showed a significant decrease from day 1 to day 9.

conclusionsThe level of HBP in CSF serves as a reliable diagnostic marker for identifying intracranial infections, particularly aiding in the identification of bacterial infections. In addition, they can be used as a valuable tool for monitoring the severity and prognosis of intracranial infection.

Indexed as

BiomarkersAdultAgedAntimicrobial Cationic PeptidesBlood ProteinsCase-Control StudiesFemaleHumansMaleMiddle AgedProcalcitoninPrognosisROC CurveAntimicrobial Cationic PeptidesAZU1 protein, humanBiomarkersBlood ProteinsProcalcitoninCerebrospinal fluidHeparin-binding proteinIntracranial infectionProcalcitonin

Identifiers

PMID39695846
PMCPMC11657152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.