Evidence map›Paper›PMID 39695743›Full record

ArticleParasites & vectors2024

Hosts and vectors of scrub typhus in Chile: epidemiological study and molecular analyses of Orientia infection in rodents and rodent-associated mites.

Constanza Martínez-Valdebenito, Gerardo Acosta-Jamett, Rayitray Abello, Ju Jiang, Allen L Richards, Katia Abarca, Thomas Weitzel

Abstract read
In one paragraph

Article in Parasites & vectors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Constanza Martínez-Valdebenito *Departamento de Enfermedades Infecciosas e Inmunología Pediátricas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Gerardo Acosta-Jamett *Instituto de Medicina Preventiva Veterinaria and Center for Disease Surveillance and Evolution of Infectious Diseases, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile.
Rayitray AbelloInstituto de Medicina Preventiva Veterinaria and Center for Disease Surveillance and Evolution of Infectious Diseases, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile.
Ju JiangNaval Medical Research Center, Silver Spring, MD, USA.
Allen L RichardsUniformed Services University of the Health Sciences, Bethesda, MD, USA.
Katia Abarca *Departamento de Enfermedades Infecciosas e Inmunología Pediátricas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. kabarca@uc.cl.
Thomas Weitzel *Laboratorio Clínico, Facultad de Medicina Clínica Alemana, Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile. thomas.weitzel@gmail.com.

Funding

Agencia Nacional de Investigación y Desarrollo FONDECYT-1170810Agencia Nacional de Investigación y Desarrollo Nº 21230036
6 · The paper itself

Abstract

Candidatus Orientia chiloensis causes scrub typhus over a wide geographical range in southern Chile. The life cycle, including vectors and reservoirs of this novel rickettsial pathogen, is incompletely understood. We analyzed rodent tissue and rodent-associated mite samples collected during a field study in six localities on Chiloé Island, where human scrub typhus cases have occurred. Using molecular methods, we detected Orientia DNA in 24.8% of rodents, belonging to five of seven captured species. Orientia-infection rates showed geographical variations, but were not influenced by rodent species, sex, age, and mite infestation. Phylogenetic analysis showed that Orientia sequences from trombiculid mites (Proschoengastia eloisae) were identical to those from scrub typhus patients from the same region. The results suggest that these rodent-associated mites serve as vectors and play an important role in the ecology of scrub typhus in southern Chile. Further studies are required to determine whether Orientia-infected rodents can also serve as reservoir of Orientia in Chile.

Indexed as

Orientia tsutsugamushiPhylogenyRodentiaScrub TyphusAnimalsChileDisease ReservoirsDisease VectorsFemaleHumansMaleMite InfestationsMitesRodent DiseasesTrombiculidaeEpidemiologyRickettsialesScrub typhusSouth AmericaVector-borne diseasesZoonotic diseases

Identifiers

PMID39695743
PMCPMC11658049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.