Evidence map›Paper›PMID 39695651›Full record

ArticleMalaria journal2024

Placental malaria and adverse pregnancy outcomes in Majang Zone of Gambella Region, Southwest Ethiopia: a histopathological and molecular study.

Aklilu Alemayehu, Hallelujah Getachew, Abdo Kedir, Melese Abere, Ahmed Zeynudin, Joseph Beyene, Delenasaw Yewhalaw

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Article in Malaria journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aklilu AlemayehuSchool of Medical Laboratory Science, Institute of Health, Jimma University, Jimma, Ethiopia. aaakealex59@gmail.com.
Hallelujah GetachewSchool of Medical Laboratory Science, Institute of Health, Jimma University, Jimma, Ethiopia.
Abdo KedirDepartment of Pathology, Institute of Health, Jimma University, Jimma, Ethiopia.
Melese AbereDepartment of Pathology, Institute of Health, Jimma University, Jimma, Ethiopia.
Ahmed ZeynudinSchool of Medical Laboratory Science, Institute of Health, Jimma University, Jimma, Ethiopia.
Joseph BeyeneDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Delenasaw YewhalawSchool of Medical Laboratory Science, Institute of Health, Jimma University, Jimma, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlacental malaria (PM) is characterized by Plasmodium parasite sequestration in the placenta. It is responsible for various adverse pregnancy outcomes, including maternal anaemia and low birth weight (LBW). This study aimed to assess prevalence and risk factors of PM, and gestational malaria (GM), together with the prevalence of congenital malaria (CM), maternal anaemia, and LBW among parturient women attending delivery ward of Metti Health Centre (Metti HC) in Majang Zone of Gambella Region, Southwest Ethiopia.

methodsA cross-sectional study involving 180 parturient women attending delivery ward of Metti HC was conducted from November 2022-March 2023. Sociodemographic, obstetric, and anti-malarial intervention data were collected. Capillary, placental and cord blood, and placental biopsy were collected to diagnose malaria using rapid diagnostic test (RDT), microscopy, quantitative polymerase chain reaction (qPCR), and histopathology. Haemoglobin concentration and blood group of the mother and weight of the newborn were determined. Statistical analyses were done by SPSS Version 26.0. Multivariable logistic regression analysis and Chi-square test were done to identify risk factors. Results were presented in text, tables and graphs.

resultsThe prevalence of GM, PM, CM, maternal anaemia, and LBW was 24.4% (95% CI 18.1-30.1), 34.4% (95% CI 27.4-41.4), 5.0% (95% CI 2.4-8.8), 41.7% (95% CI 34.6-49.0) and 27.8% (95% CI 21.6-34.6), respectively. Risk factors of GM were: presence of malaria history within the previous year (AOR: 5.10; 95% CI 1.64-15.83), lack of indoor residual spray (IRS) within the previous year (AOR: 2.98; 95% CI 1.05-8.45), and lack of antenatal care (ANC) contact during the index pregnancy (AOR: 3.96; 95% CI 1.44-10.87). Risk factors of PM were: presence of malaria history within the previous year (AOR: 2.98; 95% CI 1.05-8.45), and lack of ANC contact during the index pregnancy (AOR: 4.83; 95% CI 1.91-12.18). The risk of CM (p < 0.001), maternal anaemia (p < 0.001) and LBW (p < 0.001) increased with GM and PM.

conclusionThere is high prevalence of GM, PM, maternal anaemia, and LBW in the study area. The presence of GM and PM increased the risk of maternal anaemia, CM, and LBW. The identified risk factors should be considered to mitigate malaria among parturient women and its adverse outcomes.

Indexed as

PlacentaPregnancy Complications, ParasiticPregnancy OutcomeAdolescentAdultAnemiaCross-Sectional StudiesEthiopiaFemaleHumansInfant, Low Birth WeightInfant, NewbornMalariaPregnancyPrevalenceRisk FactorsAnaemiaCongenital malariaGambellaGestational malariaHistopathologyLow birth weightMajang ZoneMalaria in pregnancyPlacental malariaPlasmodiumPrevalenceqPCRRisk factorsSouthwest Ethiopia

Identifiers

PMID39695651
PMCPMC11658370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.