ArticleBMC psychiatry2024
Associations between serum uric acid and risk of depressive symptoms in East Asian populations.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- The association between serum uric acid and depression among U.S. National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundDespite the fact that observational studies have reported associations between serum uric acid (SUA) and depressive symptoms risk in East Asian populations, there is a lack of evidence demonstrating a causal relationship between them. This study aimed to perform a comprehensive assessment of the relationship between SUA and depressive symptoms.
methodsThis study included two cohort studies and a two-sample Mendelian randomization study. The cross-sectional cohort was derived from the China Health and Retirement Longitudinal Study (CHARLS) wave 3 (in 2015), and the baseline data of participants were extracted from the CHARLS wave 1(in 2011), excluding those with depressive symptoms in 2011 and forming a longitudinal cohort from 2011 to 2015. Logistic multiple regression was performed to investigate the cross-sectional and longitudinal associations of SUA with depressive symptoms in the two cohorts. Furthermore, we performed two-sample Mendelian randomization analyses to explore the potential causal relationships between them.
resultsWe included two cohorts of 9056 and 3177 individuals respectively. Logistic regression showed that individual with higher SUA levels had a lower risk of depressive symptoms (OR = 0.921; 95%CI: 0.886-0.957) in the cross-sectional cohort. However, neither the baseline SUA level (OR = 1.055, 95%CI: 0.961-1.157) nor the change in SUA level (OR = 0.945, 95%CI: 0.656-1.363) affected the depressive symptoms 4 years later in the longitudinal cohort. The two-sample MR showed that there was no genetic causal relationship between SUA and depression (OR
conclusionsSUA and depressive symptoms are associated, with lower SUA levels observed in middle-aged and older participants with depressive symptoms; however, no causal evidence supports their relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.