Evidence map›Paper›PMID 39695426›Full record

ArticleBMC cancer2024

Prion protein regulates invasiveness in glioblastoma stem cells.

Mariana B Prado, Bárbara P Coelho, Rebeca P Iglesia, Rodrigo N Alves, Jacqueline M Boccacino, Camila F L Fernandes, Maria Isabel Melo-Escobar, Shamini Ayyadhury, Mario C Cruz, Tiago G Santos and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mariana B Prado *Laboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Bárbara P Coelho *Laboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Rebeca P IglesiaLaboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Rodrigo N AlvesLaboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Jacqueline M BoccacinoLaboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Camila F L FernandesLaboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Maria Isabel Melo-EscobarLaboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Shamini AyyadhuryThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Mario C CruzCore Facility to Support Research - Institute of Biomedical Sciences (CEFAP), Sao Paulo, Brazil.
Tiago G SantosLaboratory of Cell and Molecular Biology, International Research Center, A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil.
Flávio H BeraldoRobarts Research Institute, Departments of Physiology and Pharmacology, Anatomy and Cell Biology, and Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Jue FanRobarts Research Institute, Departments of Physiology and Pharmacology, Anatomy and Cell Biology, and Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Frederico M FerreiraLIM50, Division of Pathology, University of São Paulo School of Medicine, São Paulo, Brazil.
Helder I NakayaDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Marco A M PradoRobarts Research Institute, Departments of Physiology and Pharmacology, Anatomy and Cell Biology, and Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Vania F PradoRobarts Research Institute, Departments of Physiology and Pharmacology, Anatomy and Cell Biology, and Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Martin L DuennwaldSchulich School of Medicine & Dentistry, Department of Pathology and Laboratory Medicine, The University of Western Ontario, London, Ontario, Canada.
Marilene H LopesLaboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil. marilenehl@usp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 101796/2020‑0Conselho Nacional de Desenvolvimento Científico e Tecnológico 409941/2021‑2Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/20271‑0Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/26158‑0Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/11097‑1Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/14741‑9Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/14952‑0Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/03714-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/07450‑5Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/08198-3Natural Sciences and Engineering Research Council of Canada 03592-2021 RGPIN
6 · The paper itself

Abstract

backgroundGlioblastoma (GBM) is an aggressive brain tumor driven by glioblastoma stem cells (GSCs), which represent an appealing target for therapeutic interventions. The cellular prion protein (PrP

methodsTo address this goal, we employed CRISPR-Cas9 technology to generate PrP

resultsTranscriptome analysis of PrP

conclusionsThese findings establish PrP

Indexed as

Brain NeoplasmsGlioblastomaNeoplasm InvasivenessNeoplastic Stem CellsCell Line, TumorCell MovementCell ProliferationCRISPR-Cas SystemsGene Expression Regulation, NeoplasticGene Knockout TechniquesHumansPrion ProteinsPrPC ProteinsPrion ProteinsPrPC ProteinsCD44Cellular prion proteinGlioblastoma stem cellsInvasionMigration

Identifiers

PMID39695426
PMCPMC11657363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.