ArticleCommunications chemistry2024
Rapid and scalable ruthenium catalyzed meta-C-H alkylation enabled by resonant acoustic mixing.
Article in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations.Angewandte Chemie (International ed. in English) · 2026Review
- Photo-induced ruthenium-catalyzed alkene C-H-arylation at room temperature.Chemical communications (Cambridge, England) · 2025Article
- Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients.ChemSusChem · 2025Article
- A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing.Nature communications · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Synthetic chemistry approaches for direct C-H bond alkylation offers a promising alternative to traditional functional-group-centered strategies which often involve multi-step procedures and may suffer from a variety of challenges including scalability. Here, we introduce resonant mixing as an efficient method for meta-C-H alkylation of arenes using a Ru-catalyst, avoiding the need for bulk solvents, external temperature, or light. The described methodology is highly rapid, enabling multigram-scale synthesis of meta-alkylation products within a short reaction time and achieving a very high turnover frequency. The reaction operates via a radical mechanism and is characterized by its mild reaction conditions, substrate compatibility, and exceptional meta-selectivity, all while significantly reducing reaction times.
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Registered trials
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