Evidence map›Paper›PMID 39695262›Full record

Observational studyPediatric research2025

Pediatric SARS-CoV-2 long term outcomes study (PECOS): cross sectional analysis at baseline.

Gina A Montealegre Sanchez, Lauren E Arrigoni, Alexandra B Yonts, Kevin B Rubenstein, James E Bost, Max T Wolff, Mallory C Barrix, W Patricia Bandettini, Bema Boateng, Dorothy I Bulas and 40 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04830852 (Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04830852 active not recruitingnot on this map

Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up

TypeobservationalSponsorChildren's National Research InstituteRan2021 to 2027Enrolled5,000ConditionsCovid19, MIS-C Associated with COVID-19, MIS-C Multisystem Inflammatory Syndrome in Children, SARS-CoV2 Infection
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Gina A Montealegre SanchezDivision of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. montealegrega@nih.gov.ORCID http://orcid.org/0009-0007-7226-4266
Lauren E ArrigoniCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Alexandra B YontsDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Kevin B RubensteinClinical Monitoring Research Program Directorate (CMRPD), National Cancer Institute Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
James E BostDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Max T WolffClinical Research Directorate (CRD), National Cancer Institute Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Mallory C BarrixCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
W Patricia BandettiniNational Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
Bema BoatengCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Dorothy I BulasDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Thomas R BurklowOffice of Clinical Research Training and Medical Education, Clinical Center (CC), NIH, Bethesda, MD, USA.
Kayla P CarlyleCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Marcus ChenNational Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
Sanchita DasDepartment of Laboratory Medicine (DLM), CC, NIH, Bethesda, MD, USA.
Robin L DewarDivision of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Austin A DixonDepartment of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, USA.
Maureen A EduCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Rachel L FalikDivision of Pediatric Infectious Diseases, Children's National Hospital, Washington, DC, USA.
Monika L GeslakCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Marcin GierdalskiCenter for Translational Research, Children's National Research Institute, Washington, DC, USA.
Ashraf S HarahshehDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Linda J HerbertDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Jeroen HighbargerDivision of Intramural Research (DIR), NIAID, NIH, Bethesda, MD, USA.
Saira R HuqCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Arthur KoCenter for Genetic Medicine Research, Children's National Research Institute, Washington, DC, USA.
Anastassios C KoumbourlisDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Stephanie R LaceyDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Andrew J LiptonNational Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
Maureen MonaghanDivision of Psychology & Behavioral Health, Children's National Hospital, Washington, DC, USA.
Anta S NdourCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Laura J OlivieriUPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Dinesh K PillaiDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Catherine A RehmDivision of Intramural Research (DIR), NIAID, NIH, Bethesda, MD, USA.
Craig A SableDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Vandana SachdevNational Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
Audrey E ThurmNational Institute of Mental Health (NIMH), NIH, Bethesda, MD, USA.
Uyen T TruongDivision of Cardiology, Children's National Hospital, Washington, DC, USA.
Evrim B TurkbeyDepartment of Radiology and Imaging Sciences, CC, NIH, Bethesda, MD, USA.
Eric VilainInstitute for Clinical and Translational Science, University of California Irvine, Irvine, CA, USA.
Shera WeyersClinical Monitoring Research Program Directorate (CMRPD), National Cancer Institute Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Jacob S WhiteCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Abigail A WilliamsCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Jonathan ZemberDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
C Jason LiangBiostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA.
Meghan DelaneyCenter for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.
Mark L BatshawDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH, Bethesda, MD, USA.
David L WesselDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Karyl BarronDivision of Intramural Research (DIR), NIAID, NIH, Bethesda, MD, USA.
Roberta L DeBiasiDepartment of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.

Funding

Characterization of host immune responses to SARS-CoV-2ZIAAI001270 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2020 to 2025
$1.2M
Intramural NIH HHS ZIA AI001270
6 · The paper itself

Abstract

backgroundPECOS is an ongoing study aimed to characterize long-term outcomes following pediatric SARS-CoV-2 infection.

methodsThis is a cross-sectional analysis of infected and uninfected cohorts at baseline. Participants (0-21 years) with laboratory-confirmed SARS-CoV-2 infection were enrolled as infected. Uninfected were defined as individuals without history or laboratory evidence of SARS-CoV-2 infection. Outcome measures included demographics, medical history, review of symptoms, physical exam, cardiopulmonary evaluation and validated psychological and developmental surveys. Primary outcomes were cohort comparisons for abnormalities on all measures.

results654 participants (541 infected, 113 uninfected) completed baseline visits by June 30, 2023. Infected participants were more likely to report constitutional (OR: 2.24), HEENT (OR: 3.74); respiratory (OR: 2.41), or gastrointestinal (OR: 2.58) symptoms. Infected had worse scores in domains of Pain, Fatigue, Global Health, Physical and Cognitive functioning, Mobility and Sleep disturbances when compared to uninfected controls using Patient Reported Outcomes. Cardiopulmonary findings were similar among cohorts.

conclusionsThe first report of this ongoing longitudinal study demonstrates that infected participants were more likely to report symptoms compared to uninfected controls, which may affect performance and quality of life of these individuals. Longitudinal data will increase understanding of long-term effects of SARS-CoV-2 infection in children. CLINICALTRIALS: gov Identifier: NCT04830852 IMPACT: This study establishes a large, diverse, prospective, longitudinal, multi-center cohort of children with history of SARS-CoV-2 infection compared to an uninfected cohort to be followed for 3 years. Cross-sectional cohort analysis at study entry showed infected participants were more likely to report constitutional, respiratory, and GI symptoms compared to uninfected controls. Infected participants were more likely to have significantly worse parent-reported performance in 6 of 10 Patient Reported Outcome Measures domains. Continued study of this cohort will help identify clinical sequelae of COVID-19, characterize the immune response to SARS-CoV-2 infection, and identify potential genetic/immunologic factors associated with long-term outcomes.

Indexed as

COVID-19AdolescentChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleYoung Adult

Identifiers

PMID39695262
PMCPMC12174577

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.