ArticleNature2025
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed.
- Lithocholic acid alleviates fatty liver in mice and non-human primate macaques.Life metabolism · 2026Article
- Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism.eLife · 2026Article
- Malic enzyme 1 senses L-lactate to determine tumor heterogeneity.Signal transduction and targeted therapy · 2026Article
- A Mechanism-Based Framework for Anti-Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell-Based Interventions.Aging cell · 2026Review
- Lysosomal Dysfunction Is Associated With Intervertebral Disc Degeneration: Multiomics and Machine Learning Identify Molecular Subtypes and Hub Genes.The journal of gene medicine · 2026Article
- ERα/SIRT1 signaling mediates the metabolic regulatory benefits of pterostilbene.The Journal of biological chemistry · 2026Article
- AMPK Therapy-A Little Goes A Long Way.Cells · 2026Review
- Fibrillarin Resists Cellular Senescence Via SIRT1-Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Lysosomes and lysosomal dysfunction in ageing biology.Nature cell biology · 2026Review
- Research progress of traditional Chinese medicine interventions for aging-related nervous system diseases.Biogerontology · 2026Review
- Gut Microbiota and Ageing: A Critical Crosstalk in Alcohol-Related Liver Disease.Microorganisms · 2026Review
- Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.MedComm · 2026Review
- Article
- Insights into the therapeutic strategies for aging and aging-associated diseases.Signal transduction and targeted therapy · 2026Review
- Epigenetic-Metabolic interplay in chronic kidney disease mortality: insights from grimage acceleration and transcriptomic profiling.Clinical epigenetics · 2026Article
- Crosstalk between lipid metabolism and epigenetics in cellular senescence and age-related diseases.npj aging · 2026Review
- Molecular mechanisms of SIRT1 in regulating ageing and related intervention strategies.Molecular biology reports · 2026Review
- Nanoengineered bile acid-mediated orchestration of versatile immuno-microbial cues for treating periodontitis.Journal of nanobiotechnology · 2026Article
- Pharmacologic AMPK Activation Extends Lifespan inbioRxiv : the preprint server for biology · 2026Article
- Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Qi Qu *State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Yan Chen *State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Yu Wang *State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.ORCID 0009-0000-5023-5260
Weiche Wang *State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Shating LongState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Heng-Ye YangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Jianfeng WuLaboratory Animal Research Centre, Xiamen University, Xiamen, China.
Mengqi LiState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.ORCID 0000-0002-1171-5648
Xiao TianState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Xiaoyan WeiState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Yan-Hui LiuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Shengrong XuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Jinye XiongState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Chunyan YangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Zhenhua WuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Xi HuangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Changchuan XieState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.ORCID 0000-0002-1078-0464
Yaying WuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Zheni XuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.ORCID 0000-0001-7926-0259
Cixiong ZhangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Baoding ZhangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Jin-Wei FengState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Junjie ChenAnalysis and Measurement Centre, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Yuanji FengState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
Huapan FangState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
Liyun LinState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Z K XieState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Beibei SunState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Huayu TianState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
Yong YuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.ORCID 0000-0002-9821-9726
Hai-Long PiaoCAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.ORCID 0000-0001-7451-0386
Xiao-Song XieMcDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-7013-4571
Xianming DengState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.ORCID 0000-0002-9354-5864
Chen-Song ZhangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. cszhang@xmu.edu.cn.ORCID 0000-0001-5218-0101
Sheng-Cai LinState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. linsc@xmu.edu.cn.ORCID 0000-0003-1993-8376
Funding
National Key R&D Program of China
Abstract
Lithocholic acid (LCA) is accumulated in mammals during calorie restriction and it can activate AMP-activated protein kinase (AMPK) to slow down ageing
Indexed as
AgingAMP-Activated Protein KinasesLithocholic AcidSirtuinsAcetylationAllosteric RegulationAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCaloric RestrictionDrosophila melanogasterEnzyme ActivationFemaleHumansLongevityLysosomesAMP-Activated Protein KinasesCaenorhabditis elegans ProteinsLithocholic AcidSirtuin 1SirtuinsVacuolar Proton-Translocating ATPases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.