Evidence map›Paper›PMID 39695231›Full record

ArticleNature2025

Determining structures of RNA conformers using AFM and deep neural networks.

Maximilia F S Degenhardt, Hermann F Degenhardt, Yuba R Bhandari, Yun-Tzai Lee, Jienyu Ding, Ping Yu, William F Heinz, Jason R Stagno, Charles D Schwieters, Norman R Watts and 4 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Automating Model Building for SPM Images of Biomolecules Using MISO.Journal of chemical information and modeling · 2026
    Article
  5. Article
  6. Article
  7. Machine Learning for RNA-Targeting Drug Design.Journal of chemical information and modeling · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. AI meets RNA: revolutionizing structure prediction.Science China. Life sciences · 2025
    Article
  18. Article
  19. Sequence and ionic requirements of pUG fold quadruplexes.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Maximilia F S DegenhardtProtein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0003-4522-377X
Hermann F DegenhardtProtein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Yuba R BhandariProtein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Yun-Tzai LeeProtein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0001-8123-6207
Jienyu DingProtein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Ping YuProtein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
William F HeinzOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-6194-0536
Jason R StagnoProtein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0002-6464-7829
Charles D SchwietersComputational Biomolecular Magnetic Resonance Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4216-4658
Norman R WattsProtein Expression Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Paul T WingfieldProtein Expression Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Alan ReinRetrovirus Assembly Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0002-8273-546X
Jinwei ZhangStructural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2114-173X
Yun-Xing WangProtein-Nucleic Acid Interaction Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA. wangyunx@mail.nih.gov.ORCID 0000-0002-2175-0148

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCI NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Much of the human genome is transcribed into RNAs

Indexed as

Microscopy, Atomic ForceNeural Networks, ComputerRNADeep LearningHumansModels, MolecularNucleic Acid ConformationSignal-To-Noise RatioUnsupervised Machine LearningRNA

Identifiers

PMID39695231
PMCPMC11779638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.