Evidence map›Paper›PMID 39695226›Full record

ArticleNature2025

Four-component protein nanocages designed by programmed symmetry breaking.

Sangmin Lee, Ryan D Kibler, Green Ahn, Yang Hsia, Andrew J Borst, Annika Philomin, Madison A Kennedy, Buwei Huang, Barry Stoddard, David Baker

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Protein design and RNA design: Perspectives.Quantitative biology (Beijing, China) · 2026
    Article
  6. Article
  7. Article
  8. Chemical reviews · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Design of solubly expressed miniaturized SMART MHCs.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sangmin Lee *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1145-4708
Ryan D Kibler *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6984-9887
Green AhnDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Yang HsiaDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7467-8373
Andrew J BorstDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4297-7824
Annika PhilominInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0008-0305-9709
Madison A KennedyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3422-9172
Buwei HuangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Barry StoddardDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2250-9601
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID http://orcid.org/0000-0001-7896-6217

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Waters Select Series Cyclic IMS for P41 Native MS Resource Application to Alzheimer's DiseaseP41GM128577 · NIGMS · OHIO STATE UNIVERSITY · PI SOMOGYI, ARPAD · 2018 to 2022
$7.6M
Designed Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5M
Biophysical and structural studies of protein and enzyme mechanism, evolution, and engineeringR35GM148166 · NIGMS · FRED HUTCHINSON CANCER CENTER · PI BARRY L. STODDARD · 2023 to 2026
$2.3M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
NIA NIH HHS R01 AG063845NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P41 GM128577NIGMS NIH HHS R35 GM148166NIH HHS S10 OD018483
6 · The paper itself

Abstract

Four, eight or twenty C3 symmetric protein trimers can be arranged with tetrahedral, octahedral or icosahedral point group symmetry to generate closed cage-like structures

Indexed as

NanostructuresProteinsModels, MolecularProtein MultimerizationProteins

Identifiers

PMID39695226
PMCPMC11821509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.