ArticleNature2025
Engineered extrachromosomal oncogene amplifications promote tumorigenesis.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Article
- Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.Molecular cancer · 2026Review
- The shared evolutionary capacities of plasmids and extrachromosomal DNA.Nature reviews. Genetics · 2026Review
- Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.Nature reviews. Urology · 2026Review
- MYC in Oncogenesis and Therapeutic Implications.MedComm · 2026Review
- A Conserved Enhancer Locus in Extrachromosomal DNA and Homogeneously Staining Regions Activates MYC Transcription in Group 3 Medulloblastoma.Cancer research · 2026Article
- Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays.Medical review (2021) · 2026Review
- Targeting extrachromosomal DNA in human cancers.Nature reviews. Drug discovery · 2026Review
- Evolution of oncogene amplification across 86,000 cancer cell genomes.bioRxiv : the preprint server for biology · 2026Article
- Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway.Research square · 2026Article
- Review
- Article
- Global Advances in Hepatocellular Carcinoma Research and Therapy in 2025.Cancer innovation · 2026Review
- ecPICK: A deep learning-enabled spatial diagnostic platform for direct ecDNA identification and clinical prognosis across pan-cancer histopathology.Theranostics · 2026Article
- Tailorable porous collagen hydrogels as a physiologically relevant platform for extrachromosomal DNA-associated colorectal cancer research.Theranostics · 2026Article
- ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment.bioRxiv : the preprint server for biology · 2025Article
- Pre-rRNAs control mitosis by maintaining chromosomal segregation through protecting SMC2 from AURKA-mediated phosphorylation.Cell death & disease · 2025Article
- Not just a by-product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B-cell leukemia.Molecular oncology · 2025Article
- Extrachromosomal DNA-Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma.Cancer discovery · 2025Article
- Extrachromosomal DNA: shaping the evolutionary dynamics of cancer.Trends in cancer · 2025Review
Corrections and comments
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Authors and funding
29 authors.
Davide Pradella *Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-8649-7817
Minsi Zhang *Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Rui Gao *Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Melissa A Yao *Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-2274-6925
Katarzyna M GluchowskaCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ylenia Cendon-FlorezCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-7525-7407
Tanmay MishraCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gaspare La RoccaCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Moritz WeiglCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ziqi JiaoCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hieu H M NguyenCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-9195-1757
Marta LisiCenter for Stem Cell Biology and Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mateusz M OzimekCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chiara MastroleoCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kevin ChenCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-0674-1411
Felix GrimmCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jens LuebeckComputer Science and Engineering, UC San Diego, La Jolla, CA, USA.ORCID 0000-0003-4391-979X
Shu ZhangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.ORCID 0000-0003-2543-5943
Andrea Alice ZolliCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eric G SunCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9109-1969
Bhargavi DameracharlaComputer Science and Engineering, UC San Diego, La Jolla, CA, USA.
Zhengqiao ZhaoLewis-Sigler Institute for Integrative Genomics and Department of Computer Science, Princeton University, Princeton, NJ, USA.
Yuri PritykinLewis-Sigler Institute for Integrative Genomics and Department of Computer Science, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-6589-981X
Carlie SigelDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9459-4393
Paul S MischelDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-4560-2211
Vineet BafnaComputer Science and Engineering, UC San Diego, La Jolla, CA, USA.
Cristina R AntonescuDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9717-8205
Andrea VenturaCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. venturaa@mskcc.org.ORCID 0000-0003-4320-9907
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MeDyNAmiC - STANFORDOT2CA278688 · NCI · STANFORD UNIVERSITY · PI PAUL S MISCHEL · 2022 to 2026
$7.7MWeill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6MSoftware and algorithms for elucidating the structure, function, and evolution of extrachromosomal DNAU24CA264379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAFNA, VINEET, MESIROV, JILL P. · 2021 to 2025
$3.5MComputational methods for detecting patterns of complex genomic variationR01GM114362 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vineet Bafna · 2016 to 2026
$3.1MRegulatory genomics of T cells in mouse and humanDP2AI171161 · NIAID · PRINCETON UNIVERSITY · PI Yury Pritykin · 2022 to 2026
$2.4MInvestigating the roles of oncogenic extrachromosomal circular DNAs in cancerR01CA282913 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Andrea Ventura · 2023 to 2026
$2.2MeDyNAmiC - UCSDOT2CA278635 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vineet Bafna · 2022 to 2026
$1.8MeDyNAmiC (extrachromosomal DNA in Cancer) - Understanding the biology of ecDNA generation and action, and developing new ways to target these mechanisms in cancerOT2CA301085 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Andrea Ventura · 2024 to 2026
$748kCancer Research UK CGCATF-2021/100012NCI NIH HHS OT2 CA278635NCI NIH HHS OT2 CA278688NCI NIH HHS OT2 CA301085NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA282913NCI NIH HHS U24 CA264379NIAID NIH HHS DP2 AI171161NIGMS NIH HHS R01 GM114362NIGMS NIH HHS T32 GM152349
Abstract
Focal gene amplifications are among the most common cancer-associated mutations
Indexed as
CarcinogenesisCell Transformation, NeoplasticGene AmplificationGenetic EngineeringOncogenesAnimalsCarcinoma, HepatocellularCell ProliferationDisease Models, AnimalFemaleHumansLiver NeoplasmsMaleMiceProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-mycMdm2 protein, mouseProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-myc
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.