Evidence map›Paper›PMID 39695135›Full record

ArticleScientific data2024

Transcriptome-wide RNA 5-methylcytosine profiles of human iPSCs and iPSC-derived cardiomyocytes.

Szu-Ying Chen, Yi-Hsien Fang, Chen-Yu Huang, Jou-Hsien Wu, Yan-Shen Shan, Yen-Wen Liu, Po-Hsien Huang

Abstract readDataset
In one paragraph

Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Caught in the crossfire: cardiac complications of cancer therapy.The Journal of clinical investigation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Szu-Ying Chen *Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yi-Hsien Fang *Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chen-Yu HuangDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jou-Hsien WuSchool of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yan-Shen ShanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-2457-5189
Yen-Wen LiuInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. wen036030@gmail.com.
Po-Hsien HuangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. phhuang@mail.ncku.edu.tw.ORCID 0000-0002-2997-5181

Funding

Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) #A1102-U015Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) MOST 110-2628-B-006-026National Cheng Kung University Hospital (NCKU Hospital) NCKUH-10909028National Cheng Kung University Hospital (NCKU Hospital) NCKUH-11009024National Cheng Kung University Hospital (NCKU Hospital) NCKUH-11109014
6 · The paper itself

Abstract

Cardiac regenerative therapy has recently progressed by reprogramming somatic cells into induced pluripotent stem cells (iPSCs) and advanced by large-scale differentiation-derived cardiomyocytes (hiPSC-CMs). However, repairing damaged cardiac tissues with hiPSC-CMs remains limited due to immune rejection, cardiac arrhythmias, and concerns over tumor formation after hiPSC-CM transplantation. Despite efforts in profiling epigenomic changes during cardiac differentiation, regulatory mechanisms underlying 5-methylcytosine (m

Indexed as

5-MethylcytosineCell DifferentiationInduced Pluripotent Stem CellsMyocytes, CardiacTranscriptomeHumans5-Methylcytosine

Identifiers

PMID39695135
PMCPMC11655970

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.