Evidence map›Paper›PMID 39695122›Full record

ArticleNature communications2024

Structural mechanism of CB

Punita Kumari, Szabolcs Dvorácskó, Michael D Enos, Karthik Ramesh, Darrix Lim, Sergio A Hassan, George Kunos, Resat Cinar, Malliga R Iyer, Daniel M Rosenbaum

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Elucidating biased signaling in class A GPCRs.Trends in pharmacological sciences · 2025
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Punita Kumari *Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Szabolcs Dvorácskó *Section on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
Michael D EnosDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-3208-7043
Karthik RameshDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Darrix LimDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sergio A HassanBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3319-078X
George KunosLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0003-1788-4976
Resat CinarSection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.ORCID 0000-0002-8597-7253
Malliga R IyerSection on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA. malliga.iyer@nih.gov.ORCID 0000-0002-0116-4619
Daniel M RosenbaumDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA. dan.rosenbaum@utsouthwestern.edu.ORCID 0000-0002-7174-4993

Funding

Structural mechanisms of Scap/SREBP signaling in membrane homeostasisR35GM136387 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniel Rosenbaum · 2020 to 2026
$3.0M
NIGMS NIH HHS R35 GM136387U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM116387Welch Foundation I-1770
6 · The paper itself

Abstract

The cannabinoid receptor 1 (CB

Indexed as

Cryoelectron MicroscopyDrug Inverse AgonismReceptor, Cannabinoid, CB1AnimalsBinding SitesHEK293 CellsHumansMolecular Dynamics SimulationProtein BindingSingle-Domain AntibodiesReceptor, Cannabinoid, CB1Single-Domain Antibodies

Identifiers

PMID39695122
PMCPMC11655885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.