Evidence map›Paper›PMID 39695096›Full record

ArticleBlood cancer journal2024

Expanded tumor-associated polymorphonuclear myeloid-derived suppressor cells in Waldenstrom macroglobulinemia display immune suppressive activity.

Vaishali Bhardwaj, Zhi-Zhang Yang, Shahrzad Jalali, Jose C Villasboas, Rekha Mudappathi, Junwen Wang, Prithviraj Mukherjee, Jonas Paludo, Xinyi Tang, Hyo Jin Kim and 5 more

Abstract read
In one paragraph

Article in Blood cancer journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vaishali BhardwajDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.
Zhi-Zhang YangDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-1468-2300
Shahrzad JalaliDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.
Jose C VillasboasDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2907-0809
Rekha MudappathiDepartment of Quantitative Health Sciences and Center for Individualized Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Junwen WangDepartment of Quantitative Health Sciences and Center for Individualized Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.ORCID 0000-0002-4432-4707
Prithviraj MukherjeeDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.
Jonas PaludoDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-7350-5531
Xinyi TangDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.
Hyo Jin KimDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.
Jordan E KrullDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-6507-8085
Kerstin WenzlDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.
Anne J NovakDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-7904-1651
Patrizia MondelloDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA. mondello.patrizia@mayo.edu.ORCID 0000-0002-0355-3757
Stephen M AnsellDivision of Hematology and Internal Medicine Mayo Clinic, Rochester, MN, USA. ansell.stephen@mayo.edu.ORCID 0000-0003-1244-6758

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Elucidating the role of IRF4 in reprogramming the tumor microenvironment in follicular lymphomaK08CA279652 · NCI · MAYO CLINIC ROCHESTER · PI Patrizia Mondello · 2024 to 2026
$534k
NCI NIH HHS K08 CA279652NCI NIH HHS P30 CA015083
6 · The paper itself

Abstract

The role of the bone marrow (BM) microenvironment in regulating the antitumor immune response in Waldenstrom macroglobulinemia (WM) remains poorly understood. Here we transcriptionally and phenotypically profiled non-malignant (CD19

Indexed as

Myeloid-Derived Suppressor CellsTumor MicroenvironmentWaldenstrom MacroglobulinemiaAgedFemaleHumansMaleMiddle AgedNeutrophils

Identifiers

PMID39695096
PMCPMC11655835

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.