Evidence map›Paper›PMID 39695066›Full record

ArticlePharmaceutical research2024

Photodegradation of Dacarbazine Catalyzed by Vitamin B

Yuka Kimura, Mayuko Suga, Kayo Nakamura, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi

Abstract read
In one paragraph

Article in Pharmaceutical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuka KimuraDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641Yamazaki, Noda-Shi, Chiba, 278-8510, Japan.
Mayuko SugaDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641Yamazaki, Noda-Shi, Chiba, 278-8510, Japan.
Kayo NakamuraDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641Yamazaki, Noda-Shi, Chiba, 278-8510, Japan.
Hidetsugu TabataDepartment of Medicinal Chemistry, Faculty of Pharma Sciences, Teikyo University, Itabashi-Ku, Tokyo, Japan.
Tetsuta OshitariDepartment of Medicinal Chemistry, Faculty of Pharma Sciences, Teikyo University, Itabashi-Ku, Tokyo, Japan.
Hideaki NatsugariDepartment of Medicinal Chemistry, Graduate School of Pharmaceutical Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Hideyo TakahashiDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641Yamazaki, Noda-Shi, Chiba, 278-8510, Japan. hide-tak@rs.tus.ac.jp.ORCID http://orcid.org/0000-0001-5965-3987

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDrug photodegradation is a matter of great concern because it can result in potency loss and adverse side effects. This study examines the light-induced degradation of dacarbazine catalyzed by vitamin B

methodsDacarbazine was irradiated with LED (405 nm) or fluorescent light in the presence of various equivalents of vitamin B

resultsDacarbazine dissolved in D

conclusionVitamin B

Indexed as

DacarbazineFlavin-Adenine DinucleotideLightPhotolysisRiboflavinAntineoplastic Agents, AlkylatingCatalysisAntineoplastic Agents, AlkylatingDacarbazineFlavin-Adenine DinucleotideRiboflavindacarbazineflavin adenine dinucleotidephotodegradationriboflavinvitamin B2

Identifiers

PMID39695066
PMCPMC11682012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.