Evidence map›Paper›PMID 39695049›Full record

ReviewReviews in endocrine & metabolic disorders2025

Effects of growth hormone-releasing hormone deficiency in mice beyond growth.

Lucia Recinella, Maria Loreta Libero, Luigi Brunetti, Alessandra Acquaviva, Annalisa Chiavaroli, Giustino Orlando, Riccarda Granata, Roberto Salvatori, Sheila Leone

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mention to Prof. Andrew V. Schally.Reviews in endocrine & metabolic disorders · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucia Recinella *Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Maria Loreta Libero *Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Luigi BrunettiDepartment of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy. luigi.brunetti@unich.it.
Alessandra AcquavivaDepartment of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Annalisa ChiavaroliDepartment of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Giustino OrlandoDepartment of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Riccarda GranataDepartment of Medical Sciences, University of Turin, Turin, Italy.
Roberto SalvatoriDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sheila LeoneDepartment of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper provides a critical overview on GHRH and its deficiency, discussing its multiple roles in both central and peripheral tissues. Genetically engineered mice have been instrumental in elucidating the multifaceted roles of GHRH and GH, each offering unique insights into the physiological and pathological roles of these hormones, although in many of these models dissecting the direct effect of GHRH from the effect of GH is not possible. Key findings highlight the effects of GHRH deficiency on emotional behavior, including anxiety and depression, its impact on memory and learning capabilities, as well as on adipose tissue, immune system, inflammation and pain.

Indexed as

Growth Hormone-Releasing HormoneAnimalsAnxietyDepressionGrowth HormoneHumansMiceGrowth HormoneGrowth Hormone-Releasing HormoneGHDGHRHKOMouse models

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.