Evidence map›Paper›PMID 39695043›Full record

ArticleBreast cancer (Tokyo, Japan)2025

Prognostic impact of tumor‑associated stroma in triple-negative breast cancer.

Akinari Kakumoto, Tsengelmaa Jamiyan, Ai Koyanagi, Hajime Kuroda, Rin Yamaguchi, Hitoshi Tsuda, Akira Hirano, Shunichi Shiozawa

Abstract read
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In one paragraph

Article in Breast cancer (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akinari Kakumoto *Department of Diagnostic Pathology, Tokyo Women's Medical University Adachi Medical Center, 4-33-1 Kohoku, Adachi-ku, Tokyo, 123-8558, Japan.
Tsengelmaa Jamiyan *Department of Pathology and Forensic Medicine, Mongolian National University of Medical Sciences, Ulan Bator, 14210, Mongolia.
Ai KoyanagiDepartment of Diagnostic Pathology, Tokyo Women's Medical University Adachi Medical Center, 4-33-1 Kohoku, Adachi-ku, Tokyo, 123-8558, Japan.
Hajime KurodaDepartment of Diagnostic Pathology, Tokyo Women's Medical University Adachi Medical Center, 4-33-1 Kohoku, Adachi-ku, Tokyo, 123-8558, Japan. kuroda.hajime@twmu.ac.jp.ORCID http://orcid.org/0000-0001-6546-5317
Rin YamaguchiDepartment of Diagnostic Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8521, Japan.
Hitoshi TsudaDepartment of Pathology II, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Akira HiranoDepartment of Breast Surgery, Tokyo Women's Medical University Adachi Medical Center, 4-33-1 Kohoku, Adachi-ku, Tokyo, 123-8558, Japan.
Shunichi ShiozawaDepartment of Surgery, Tokyo Women's Medical University Adachi Medical Center, 4-33-1 Kohoku, Adachi-ku, Tokyo, 123-8558, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo establish the histological categorization of tumor‑associated stroma (TAS) that reflects the biological behavior of triple-negative breast cancer (TNBC). METHODS AND

resultsOne-hundred-and-twenty surgically resected cases of TNBC were examined. We histologically categorized the TAS in the invasive frontal region into two groups: mature stroma (MS) and immature stroma (IS). The designation of IS was applied for tumors in which the largest myxoid stroma filled a high-power magnification field. When there were no myxoid stroma that meet the criteria for IS, TAS was categorized as MS. The tumors with type MS were observed in 103 (85.8%) of patients, whereas 17 (14.2%) of patients had tumors with IS. In total, 72 out of 120 patients with TNBC exhibited high tumor-infiltrating lymphocytes (TILs) representing 60% of the cohort. The incidences of high TILs were 66% (68 out of 103) in the MS group but only 23.5% (4 of 17) in the IS group (p = 0.001). Progression-free survival (PFS) and overall survival (OS) curves were different between IS and MS groups (p < 0.001 each), and Cox multivariate regression analysis revealed that IS was an independent indicator for lower PFS and OS rates (p < 0.001; p = 0.008).

conclusionOur findings suggest that TAS characteristics, particularly the distinction between IS and MS, play a significant role in the prognosis of TNBC. The presence of IS, associated with poor prognosis and low TILs, contrasts with the favorable outcomes observed in cases with MS. Understanding these TAS dynamics could aid in identifying patients with varying prognostic outcomes in TNBC, necessitating further research into the mechanisms behind these observations.

Indexed as

Lymphocytes, Tumor-InfiltratingStromal CellsTriple Negative Breast NeoplasmsAdultAgedFemaleHumansMiddle AgedPrognosisProgression-Free SurvivalRetrospective StudiesTriple-negative breast cancerTumor-associated stromaTumor-infiltrating lymphocytes

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