Evidence map›Paper›PMID 39695030›Full record

ArticleJournal of molecular histology2024

Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys.

Judielson Ribeiro Gomes, Marcus Vinícius de Moraes, Flávio Santos da Silva, Isadora Luísa Gomes da Silva, Raimundo Fernandes de Araújo Júnior, Karina Paula de Paula Medeiros, Bento João Abreu, Naisandra Silva da Silva Farias

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Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Judielson Ribeiro GomesDepartment of Nursing, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID http://orcid.org/0000-0001-7567-0605
Marcus Vinícius de MoraesCenter of Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID http://orcid.org/0000-0002-7817-3433
Flávio Santos da SilvaDepartment of Health Sciences, Federal Rural University of the Semi-Arid, Mossoró, Brazil.ORCID http://orcid.org/0000-0002-7019-0482
Isadora Luísa Gomes da SilvaDepartment of Morphology, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID http://orcid.org/0009-0009-8422-6712
Raimundo Fernandes de Araújo JúniorDepartment of Morphology, Federal University of Rio Grande do Norte, Natal, Brazil.
Karina Paula de Paula MedeirosDepartment of Morphology, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID http://orcid.org/0000-0002-7784-0740
Bento João AbreuDepartment of Morphology, Federal University of Rio Grande do Norte, Natal, Brazil. abreubj@gmail.com.ORCID https://orcid.org/0000-0001-8010-806X
Naisandra Silva da Silva FariasDepartment of Morphology, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID http://orcid.org/0000-0003-0828-109X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is one of the most relevant and prevalent microvascular complications associated with Diabetes Mellitus. In recent years, hyperbaric oxygen therapy (HBO) has been used to mitigate tissue damage caused by hypoxia, thereby attenuating inflammatory processes. This study aimed to explore morphological aspects associated with DN in rats subjected to HBO. Forty-eight Wistar rats were divided into the following groups: C (normoglycemic animals), n = 12; C + HBO (normoglycemic animals submitted to HBO), n = 12; D (diabetic animals) n = 12; D + HBO (diabetic animals submitted to HBO), n = 12. The C + HBO and D + HBO groups were daily treated with HBO at 2.5 atmospheres absolute pressure (ATA) for 60 min, 5 days a week, for 5 weeks. Kidneys were collected for assessment of structural changes in the tissue parenchyma, assessment of renal fibrosis and renal protein expression of tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1). Our results showed that group D had hyperglycemia and weight loss, and that there was also an increase in the renal corpuscle, Bowman's space, and distal tubular epithelium, as well as accumulation of collagen. HBO administration effectively prevented glomerular hypertrophy and attenuated the expression of TNF-α and TGF-β1. It also positively affected renal tubules, inhibiting the development of tubular atrophy. These findings suggest that HBO was effective in attenuating the initial alterations observed in DN.

Indexed as

Diabetic NephropathiesHyperbaric OxygenationKidney Tubules, DistalTransforming Growth Factor beta1UrotheliumAnimalsAtrophyCollagenDiabetes Mellitus, ExperimentalFibrosisKidney GlomerulusRatsRats, WistarStreptozocinTumor Necrosis Factor-alphaCollagenStreptozocinTransforming Growth Factor beta1Tumor Necrosis Factor-alphaDiabetes mellitusDiabetic nephropathiesHyperbaric oxygenationRenal tissue

Identifiers

PMID39695030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.