Evidence map›Paper›PMID 39695002›Full record

ArticleAnnals of biomedical engineering2025

Metabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated Microgravity.

Annika R Bergstrom, Matthew G Glimm, Eden A Houske, Gwendolyn Cooper, Ethan Viles, Marrin Chapman, Katherine Bourekis, Hope D Welhaven, Priyanka P Brahmachary, Alyssa K Hahn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Annika R BergstromDepartment of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA.
Matthew G GlimmDepartment of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA.
Eden A HouskeDepartment of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA.
Gwendolyn CooperMolecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA.
Ethan VilesMolecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA.
Marrin ChapmanDepartment of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA.
Katherine BourekisDepartment of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA.
Hope D WelhavenMolecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA.
Priyanka P BrahmacharyDepartment of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA.
Alyssa K HahnDepartment of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA. alyssahahn19@gmail.com.ORCID http://orcid.org/0000-0002-8884-2610
Ronald K JuneDepartment of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA. rjune@montana.edu.ORCID http://orcid.org/0000-0003-0752-4109

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
Role of Glucose metabolism in Chondrocyte MechanotransductionR01AR073964 · NIAMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI JUNE, RONALD KENT · 2019 to 2024
$2.4M
Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for MetabolomicsS10OD028650 · OD · MONTANA STATE UNIVERSITY - BOZEMAN · PI BOTHNER, BRIAN P · 2020 to 2020
$599k
Division of Civil, Mechanical and Manufacturing Innovation 1554708M.J. Murdock Charitable Trust FSU-2017207Montana Space Grant Consortium 80NSSC20M0042NIAMS NIH HHS R01 AR073964NIAMS NIH HHS R01AR073964NIGMS NIH HHS P20 GM103474NIGMS NIH HHS P20GM103474NIGMS NIH HHS S10OD28650NIH HHS S10 OD028650
6 · The paper itself

Abstract

The mechanism by which chondrocytes respond to reduced mechanical loading environments and the subsequent risk of developing osteoarthritis remains unclear. This is of particular concern for astronauts. In space the reduced joint loading forces during prolonged microgravity (10

Indexed as

ChondrocytesMetabolomeWeightlessnessWeightlessness SimulationHumansOsteoarthritisArticular cartilageChondrocyte mechanotransductionLiquid chromatography-mass spectrometryMetabolomicsMicrogravity

Identifiers

PMID39695002
PMCPMC11836148

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.