Evidence map›Paper›PMID 39694607›Full record

ArticleAutophagy2025

Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation.

Van Bui, Xinwen Liang, Yansheng Ye, William Giang, Fang Tian, Yoshinori Takahashi, Hong-Gang Wang

Abstract read
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Autophagy · 2026
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Van BuiDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-6717-0552
Xinwen LiangDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Yansheng YeDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
William GiangAdvanced Light Microscopy Core Facility, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Fang TianDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-5881-6155
Yoshinori TakahashiDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-8004-4817
Hong-Gang WangDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0003-0551-0571

Funding

Autophagosome closure by the ESCRT machineryR01GM127954 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WANG, HONG-GANG · 2018 to 2025
$2.7M
Structural and Molecular Basis of Human ATG3 Activation and Regulation for LC3 Lipid Conjugation in AutophagyR01GM127730 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI TIAN, FANG · 2019 to 2022
$1.7M
NIGMS NIH HHS R01 GM127730NIGMS NIH HHS R01 GM127954
6 · The paper itself

Abstract

Macroautophagy/autophagy, an evolutionarily conserved cellular degradation pathway, involves phagophores that sequester cytoplasmic constituents and mature into autophagosomes for subsequent lysosomal delivery. The

Indexed as

AutophagosomesAutophagyAutophagy-Related Protein 8 FamilyNutrientsAnimalsAutophagy-Related ProteinsHumansMammalsMiceMicrotubule-Associated ProteinsAutophagy-Related Protein 8 FamilyAutophagy-Related ProteinsMicrotubule-Associated ProteinsNutrientsAutophagosome closureESCRTLIRmembrane expansionphagophore formationThe mammalian Atg8 family of proteins

Identifiers

PMID39694607
PMCPMC12013414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.