Evidence map›Paper›PMID 39694489›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Crohn's Disease with Granulomatous Interstitial Nephritis as an Extraintestinal Complication from the Time of the Diagnosis.

Naohiro Itoh, Kenji Kasuno, Motoko Yasutomi, Shohei Kamekawa, Izumi Itoh, Taihei Hayashi, Tatsushi Naito, Yoshiaki Imamura, Yasunari Nakamoto, Yusei Ohshima

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naohiro ItohDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Japan.
Kenji KasunoDepartment of Nephrology, Faculty of Medical Sciences, University of Fukui, Japan.
Motoko YasutomiDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Japan.
Shohei KamekawaDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Japan.
Izumi ItohDepartment of Nephrology, Faculty of Medical Sciences, University of Fukui, Japan.
Taihei HayashiDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Japan.
Tatsushi NaitoSecond Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan.
Yoshiaki ImamuraDivision of Diagnostic Pathology/Surgical Pathology, University of Fukui Hospital, Japan.
Yasunari NakamotoSecond Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan.
Yusei OhshimaDepartment of Pediatrics, Faculty of Medical Sciences, University of Fukui, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Granulomatous interstitial nephritis (GIN) has been reported in <0.5% of patients with inflammatory bowel disease, and most cases of GIN are drug-induced. A 13-year-old boy was referred for the evaluation of abdominal pain, diarrhea, and weight loss. The patient was diagnosed with non-drug-induced GIN and Crohn's disease based on total colonoscopy and a biopsy of the colon and kidney. Both tissues contained macrophages and increased epithelial expression of IκBζ, a protein involved in the nuclear factor kappa-light-chain-enhancer of activated B cells pathway. There may be more patients with GIN complicated by Crohn's disease than expected, and macrophages may be involved in the pathogenesis.

Indexed as

Crohn DiseaseGranulomaNephritis, InterstitialAdolescentColonoscopyHumansMaleCrohn's diseasegranulomatous interstitial nephritisinflammatory bowel diseasemacrophageNFKBIZ

Identifiers

PMID39694489
PMCPMC12287583

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.