Evidence map›Paper›PMID 39694413›Full record

ArticleCellular and molecular gastroenterology and hepatology2025

PRRX1 Has Functional Roles in Pancreatic Acinar to Ductal Metaplasia and Carcinogenesis.

Noriyuki Nishiwaki, Kensuke Sugiura, Kensuke Suzuki, Alina L Li, Constanza Tapia Contreras, Gizem Efe, Alice E Shin, Dorsay Sadeghian, Jun Zhao, Anirban Maitra and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Noriyuki NishiwakiDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Kensuke SugiuraDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Department of General Surgery, Chiba University, Chiba, Japan.
Kensuke SuzukiDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Department of General Surgery, Chiba University, Chiba, Japan.
Alina L LiDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Constanza Tapia ContrerasDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Gizem EfeDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Alice E ShinDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.
Dorsay SadeghianDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Sheikh Ahmed Pancreatic Cancer Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jun ZhaoDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Sheikh Ahmed Pancreatic Cancer Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Anirban MaitraDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Sheikh Ahmed Pancreatic Cancer Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jason R PitarresiDivision of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan School of Medicine, Worchester, Massachusetts.
Peter A SimsDepartment of Systems Biology, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Digestive and Liver Disease Research Center, Columbia University, New York, New York.
Rohit ChandwaniDepartment of Surgery and Cell and Developmental Biology, Meyer Cancer Center, Weill-Cornell Medicine, New York, New York.
Anil K RustgiDivision of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Digestive and Liver Disease Research Center, Columbia University, New York, New York. Electronic address: magness@med.unc.edu.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
The Prrx-1 transcription factor in pancreatic ductal biologyR01DK060694 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI CHANDWANI, ROHIT, RUSTGI, ANIL K · 2002 to 2025
$8.3M
Defining the molecular determinants of inflammatory memory in the pancreasR01DK138154 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Rohit Chandwani · 2024 to 2026
$1.5M
Multidisciplinary Training in Gastrointestinal CancersT32CA285274 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Julian Abrams, Anil K Rustgi · 2024 to 2026
$897k
Elucidating the role of Fra1 in pancreatic Kras-driven acinar to ductal metaplasiaF30DK134109 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LI, ALINA LIN · 2022 to 2024
$150k
NCI NIH HHS P30 CA013696NCI NIH HHS T32 CA285274NIDDK NIH HHS R01 DK060694NIDDK NIH HHS R01 DK138154
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39694413
PMCPMC11954830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.