Evidence map›Paper›PMID 39694231›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2025

Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study.

Iván Martínez-Baz, Ana Navascués, Camino Trobajo-Sanmartín, Francisco Pozo, Miguel Fernández-Huerta, Maddi Olazabal-Arruiz, Lucía Argente-Colas, Guillermo Ezpeleta, Aitziber Echeverria, Itziar Casado and 2 more

Abstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Iván Martínez-BazInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain. Electronic address: imartinba@navarra.es.
Ana NavascuésInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, Spain.
Camino Trobajo-SanmartínInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
Francisco PozoCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain.
Miguel Fernández-HuertaInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, Spain.
Maddi Olazabal-ArruizInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, Spain.
Lucía Argente-ColasInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, Spain.
Guillermo EzpeletaInstituto de Salud Pública de Navarra, Pamplona, Spain.
Aitziber EcheverriaInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
Itziar CasadoInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
Carmen EzpeletaInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, Spain.
Jesús CastillaInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe estimated the influenza vaccination effectiveness (IVE) in preventing medical consultations and hospitalizations due to influenza during the 2023/24 season.

methodsTwo test-negative case-control studies analyzed patients who consulted primary healthcare or were hospitalized for respiratory symptoms and were tested for influenza by PCR in the 2023/24 season in Navarre, Spain. Influenza vaccination status in the current and previous seasons was compared between confirmed influenza cases and test-negative controls. IVE was calculated as (1-adjusted odds ratio)×100.

resultsOf 3133 hospitalized patients, 529 (17%) were positive for influenza: 71% A/H1N1, 23% A/H3N2, and 7% A nonsubtyped. IVE to prevent hospitalizations was 43% (95%CI: 26%, 56%) overall, 61% (95%CI: 32%, 77%) in people younger than 65 years old and 35% (95%CI: 10%, 53%) in older people. IVE was 48% (95%CI: 30%, 61%) against influenza A/H1N1, and 15% (95%CI: -42%, 49%) against influenza A/H3N2. IVE in people vaccinated only in the previous season was 28% (95%CI: -5%, 51%). Among 417 outpatients, 146 (35%) were confirmed for influenza. IVE to prevent outpatient cases was 49% (95%CI: -9%, 76%) overall and 42% (95%CI: -33%, 74%) against influenza A/H1N1.

conclusionsIVE was moderate against influenza A/H1N1 and low against influenza A/H3N2 in the 2023/24 season.

Indexed as

HospitalizationInfluenza, HumanInfluenza VaccinesVaccine EfficacyAdolescentAdultAgedAged, 80 and overCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza Vaccinescase-control studyInfluenzainfluenza vaccineprevious vaccinationvaccine effectiveness

Identifiers

PMID39694231
PMCPMC11735411

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.