ArticleThe Angle orthodontist2025
Evaluation of IL-8 and IL-6 levels in gingival crevicular fluid of individuals undergoing clear aligner therapy.
Article in The Angle orthodontist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Antibiofilm Activity of a Thermoformable Material Loaded With Essential Oil Solution.Clinical and experimental dental research · 2026Article
- Cytotoxicity assessment of LuxCreo and Nylon direct-printed photopolymers for orthodontic applications: An in vitro study.Clinical oral investigations · 2026Article
- Clear Aligner Therapy and Marginal Edge Design: Clinical and Laboratory Evidence on Periodontal and Biological Outcomes-A Scoping Review.Dentistry journal · 2026Review
- Validation of a fast LC-MS/MS method for the analysis of bisphenol A (BPA) and urethane dimethacrylate (UDMA) in eluates of dental polymer-based materials.Scientific reports · 2026Article
- Oncolytic adenovirus encoding a TGF-β inhibitor synergizes with PD-1 blockade to potentiate NK cell cytotoxicity against NSCLC.Frontiers in immunology · 2026Article
- The Role of Cytokines in Orthodontic Tooth Movement.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare short-term changes in the levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in the gingival crevicular fluid (GCF) of individuals undergoing orthodontic treatment with clear aligners. MATERIALS AND
methodsThis study included 15 individuals. Each patient used clear aligners designed not to cause tooth movement in the GCF sampled teeth, to be changed every 10 days. GCF samples were collected from teeth 16 (upper right first molar) and 31 (lower left central incisor) at baseline and after the procedure at the first hour, third, seventh, 14th, and 21st days. In addition, clinical periodontal parameters for the full mouth and the teeth from which GCF was collected were recorded initially and on the 21st day.
resultsA statistically significant difference was observed between the levels of IL-8 before the procedure, on the third and seventh days, and on the 21st day (P < .01). The increase in IL-6 levels on the 14th and 21st days was significantly different compared to the levels before the procedure (P < .01). A positive correlation was detected between IL-8 and IL-6 levels at the first hour, a negative correlation on the third day, and a lower level of positive correlation on the seventh, 14th, and 21st days.
conclusionsWithin 21 days, the levels of IL-8 and IL-6 significantly increased in individuals undergoing orthodontic treatment with clear aligners. Within the limits of this study, the clear aligner material may affect the levels of IL-8 and IL-6 in the GCF.
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