Evidence map›Paper›PMID 39693703›Full record

ArticleMultiple sclerosis and related disorders2025

Comparison of practice-related changes in dual task walking performance and neural efficiency between older adults with progressive and relapsing-remitting multiple sclerosis.

Manuel E Hernandez, Robert W Motl, Frederick W Foley, Meltem Izzetoglu, Mark Wagshul, Roee Holtzer

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manuel E HernandezDepartment of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA; Department of Kinesiology and Community Health, College of Applied Health Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA; Neuroscience Program, College of Liberal Arts & Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA; Beckman Institute, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Robert W MotlDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.
Frederick W FoleyFerkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA; Multiple Sclerosis Center, Holy Name Medical Center, Teaneck, NJ, USA.
Meltem IzzetogluVillanova University, Electrical and Computer Engineering, Villanova, PA, USA.
Mark WagshulDepartment of Radiology, Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Roee HoltzerFerkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: roee.holtzer@einsteinmed.edu.

Funding

Brain Predictors of Mobility and Falls in Older Adults with Multiple SclerosisR01NS109023 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HOLTZER, ROEE · 2019 to 2023
$3.4M
NINDS NIH HHS R01 NS109023
6 · The paper itself

Abstract

backgroundThere is limited research comparing both performance and brain control of walking between older adults with progressive and relapsing-remitting MS.

objectiveThis study compared older adults with progressive and relapsing-remitting MS for differences in prefrontal cortex (PFC) activation in single- and dual-task-walking and practice-related effects on neural efficiency, walking, and cognitive performances.

methodsOlder adults with progressive (n = 32, age=65±6ys) and relapsing-remitting (n = 63, age=65±4ys) MS completed three conditions (single-task walk, single-task-alpha, i.e., cognitive interference task, and dual-task-walk) with three repeated trials wherein we measured PFC oxygenated hemoglobin (HbO

resultsThe task-related (i.e. single-to-dual task walking) increase in PFC HbO

conclusionsPractice-related improvements in cognitive and motor performances coupled with reduced PFC HbO

Indexed as

Multiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingPractice, PsychologicalPrefrontal CortexPsychomotor PerformanceWalkingAgedFemaleHumansMaleMiddle AgedMultiple sclerosisProgressiveWalking, Cognition, Functional-near-infrared-spectroscopy

Identifiers

PMID39693703
PMCPMC12035826

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.