Evidence map›Paper›PMID 39693475›Full record

ArticleCancer discovery2025

Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States.

Sally L George, Claire Lynn, Reda Stankunaite, Debbie Hughes, Carolin M Sauer, Jane Chalker, Saira Waqar Ahmed, Minou Oostveen, Paula Z Proszek, Lina Yuan and 44 more

Abstract read
In one paragraph

Article in Cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk Neuroblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Sally L George *Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0003-2777-4922
Claire Lynn *Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-2630-4075
Reda Stankunaite *Paediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0003-3977-7020
Debbie HughesClinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.ORCID 0009-0006-2053-1812
Carolin M SauerEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.ORCID 0000-0003-2168-6630
Jane ChalkerDepartment of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.ORCID 0009-0000-1512-6966
Saira Waqar AhmedDepartment of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.ORCID 0009-0005-2565-7417
Minou OostveenDepartment of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.ORCID 0000-0001-9674-8870
Paula Z ProszekClinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-0780-6790
Lina YuanClinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-2873-5565
Ridwan ShaikhClinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.ORCID 0009-0003-9179-0748
Sabri JamalClinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-2444-9633
Ama BrewClinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.ORCID 0009-0001-2090-9348
Jennifer TallPaediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.ORCID 0009-0006-1502-0436
Tony RogersPaediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.ORCID 0009-0009-1194-3542
Steven C CliffordWolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0003-4893-2184
Josef VormoorPrincess Máxima Center and University Medical Center, Utrecht, the Netherlands.ORCID 0000-0002-1825-1890
Janet M ShipleyDivision of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-6748-8678
Deborah A TweddleWolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0003-2208-3970
Chris JonesDivision of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-8118-2296
Courtney WillisRoyal Aberdeen Children's Hospital, Aberdeen, United Kingdom.ORCID 0009-0008-3829-8363
G A Amos BurkeCambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.ORCID 0000-0003-2671-9972
Aditi VediCambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.ORCID 0000-0001-6761-6510
Lisa HowellAlder-Hey Children's Hospital, Liverpool, United Kingdom.ORCID 0000-0003-2119-2630
Robert JohnstonRoyal Belfast Hospital for Sick Children, Belfast, United Kingdom.ORCID 0009-0002-3280-9181
Helen ReesBristol Royal Hospital for Children, Bristol, United Kingdom.ORCID 0009-0007-6867-932X
Madeleine AdamsNoah's Ark Children's Hospital for Wales, Cardiff, United Kingdom.ORCID 0000-0001-6169-1149
Angela JesudasonRoyal Hospital for Sick Children, Edinburgh, United Kingdom.ORCID 0000-0002-9278-1304
Milind RongheRoyal Hospital for Children, Glasgow, United Kingdom.ORCID 0000-0002-1865-9335
Martin ElliottLeeds General Infirmary, Leeds, United Kingdom.ORCID 0000-0002-0167-9700
Emma RossLeicester Royal Infirmary, Leicester, United Kingdom.ORCID 0000-0002-1179-0592
Guy MakinRoyal Manchester Children's Hospital, Manchester, United Kingdom.ORCID 0000-0003-3513-3957
Quentin Campbell-HewsonGreat North Children's Hospital, Newcastle upon Tyne, United Kingdom.ORCID 0000-0003-1509-6925
Richard G GrundyQueen's Medical Centre, Nottingham, United Kingdom.ORCID 0000-0002-2585-2539
Jennifer TurnbullQueen's Medical Centre, Nottingham, United Kingdom.ORCID 0009-0001-4066-5571
Shaun WilsonJohn Radcliffe Hospital, Oxford, United Kingdom.ORCID 0000-0002-3825-6525
Victoria LeeSheffield Children's Hospital, Sheffield, United Kingdom.ORCID 0009-0008-6729-6746
Juliet C GraySouthampton General Hospital, Southampton, United Kingdom.ORCID 0000-0002-5652-4722
Sara StonehamUniversity College London, London, United Kingdom.ORCID 0000-0001-5482-648X
Susanne A GatzInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-6438-9778
Lynley V MarshallPaediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-6537-2118
Paola AngeliniChildren and Young People's Unit, The Royal Marsden Hospital, London, United Kingdom.ORCID 0000-0001-5930-3530
John AndersonDepartment of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.ORCID 0000-0001-7509-3203
George D CresswellCentre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0003-3303-068X
Trevor A GrahamCentre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-9582-1597
Bissan Al-LazikaniDepartment of Genomic Medicine and the Therapeutics Discovery Division, MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0003-3367-2519
Isidro Cortés-CirianoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.ORCID 0000-0002-2036-494X
Pamela KearnsInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-2756-5813
J Ciaran HutchinsonDepartment of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.ORCID 0000-0002-1708-2634
Darren HargraveDevelopmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, United Kingdom.ORCID 0000-0001-8219-9807
Thomas S JacquesDepartment of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.ORCID 0000-0002-7833-2158
Michael HubankClinical Genomics, Centre for Molecular Pathology, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-2901-0742
Andrea SottorivaCentre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-6709-9533
Louis CheslerPaediatric Oncology Experimental Medicine Centre (POEM), The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-7842-2068

Funding

American Institute for Cancer Research (AICR) A26815Cancer Research UK (CRUK) A22909Cancer Research UK (CRUK) A24566CHILDREN with CANCER UK 17-235Higher Education Funding Council for England (HEFCE)Wellcome TrustWellcome Trust (WT) 202778/B/16/Z
6 · The paper itself

Abstract

significanceIn tumors of childhood, we identify mutations in epigenetic genes as drivers of relapse, with matched cfDNA sequencing showing significant intratumor genetic heterogeneity and cell-state specific patterns of chromatin accessibility. This highlights the power of cfDNA analysis to identify both genetic and epigenetic drivers of aggressive disease in pediatric cancers.

Indexed as

Cell-Free Nucleic AcidsEpigenesis, GeneticNeoplasmsBiomarkers, TumorChildFemaleHigh-Throughput Nucleotide SequencingHumansMaleMutationBiomarkers, TumorCell-Free Nucleic Acids

Identifiers

PMID39693475
PMCPMC11962403

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.