Evidence map›Paper›PMID 39693451›Full record

ReviewThe Journal of bone and joint surgery. American volume2025

Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair.

Ting Cong, Kyle W Morse, Branden R Sosa, Joseph M Lane, Scott A Rodeo, Matthew B Greenblatt

Abstract readReview
In one paragraph

Review in The Journal of bone and joint surgery. American volume, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ting CongDepartment of Orthopaedic Surgery, UPMC Sports Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.ORCID 0000-0003-4262-4674
Kyle W MorseHospital for Special Surgery, New York, NY.
Branden R SosaHospital for Special Surgery, New York, NY.ORCID 0000-0002-1054-2917
Joseph M LaneHospital for Special Surgery, New York, NY.
Scott A RodeoHospital for Special Surgery, New York, NY.ORCID 0000-0002-0745-9880
Matthew B GreenblattDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.

Funding

Discovery of a stem cell driving breast cancer spine metastasesR01CA282815 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Matthew Blake Greenblatt · 2024 to 2026
$2.4M
"Establishing Pathways for Endothelial Support of Bone Formation with SLIT3"R01AR075585 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENBLATT, MATTHEW BLAKE · 2020 to 2024
$1.8M
A skeletal stem cell orchestrating limb regenerationR01HD115274 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI Matthew Blake Greenblatt, Xu Yang · 2024 to 2026
$1.8M
Discovery of a stem cell governing vertebral physiologyR01AR083462 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Matthew Blake Greenblatt · 2024 to 2026
$1.5M
NCI NIH HHS R01 CA282815NIAMS NIH HHS R01 AR075585NIAMS NIH HHS R01 AR083462NICHD NIH HHS R01 HD115274
6 · The paper itself

Abstract

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

Indexed as

Bone and BonesStem CellsAnimalsHumans

Identifiers

PMID39693451
PMCPMC11839314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.