Evidence map›Paper›PMID 39693434›Full record

ArticleScience advances2024

The nucleocapsid architecture and structural atlas of the prototype baculovirus define the hallmarks of a new viral realm.

Bronte A Johnstone, Joshua M Hardy, Jungmin Ha, Anamarija Butkovic, Paulina Koszalka, Cathy Accurso, Hariprasad Venugopal, Alex de Marco, Mart Krupovic, Fasséli Coulibaly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bronte A JohnstoneInfection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0003-3313-5553
Joshua M HardyInfection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-8014-8552
Jungmin HaInfection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-1322-4658
Anamarija ButkovicInstitut Pasteur, Université Paris Cité, CNRS UMR6047, Archaeal Virology Unit, 75015, Paris, France.
Paulina KoszalkaInfection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Cathy AccursoInfection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Hariprasad VenugopalRamaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-5230-2973
Alex de MarcoInfection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Mart KrupovicInstitut Pasteur, Université Paris Cité, CNRS UMR6047, Archaeal Virology Unit, 75015, Paris, France.ORCID 0000-0001-5486-0098
Fasséli CoulibalyInfection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0003-3380-2117

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Baculovirus is the most studied insect virus owing to a broad ecological distribution and ease of engineering for biotechnological applications. However, its structure and evolutionary place in the virosphere remain enigmatic. Using cryo-electron microscopy, we show that the nucleocapsid forms a covalently cross-linked helical tube protecting a highly compacted 134-kilobase pair DNA genome. The ends of the tube are sealed by the base and cap substructures, which share a 126-subunit hub but differ in components that promote actin tail-mediated propulsion and nuclear entry of the nucleocapsid, respectively. Unexpectedly, sensitive searches for hidden evolutionary links show that the morphogenetic machinery and conserved oral infectivity factors originated within the lineage of baculo-like viruses (class

Indexed as

BaculoviridaeCryoelectron MicroscopyNucleocapsidAnimalsGenome, ViralModels, MolecularPhylogeny

Identifiers

PMID39693434
PMCPMC11654684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.