Evidence map›Paper›PMID 39693425›Full record

ArticleScience advances2024

The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence.

UnJin Lee, Deanna Arsala, Shengqian Xia, Cong Li, Mujahid Ali, Nicolas Svetec, Christopher B Langer, Débora R Sobreira, Ittai Eres, Dylan Sosa and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Autophagy · 2026
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

UnJin LeeDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-2424-650X
Deanna ArsalaDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-8950-9572
Shengqian XiaDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9264-3649
Cong LiLaboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA.ORCID 0009-0008-5255-5215
Mujahid AliDepartment of Neuroscience and Developmental Biology, University of Vienna, Vienna, Austria.ORCID 0000-0003-3583-493X
Nicolas SvetecLaboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA.ORCID 0000-0001-9617-2752
Christopher B LangerLaboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA.ORCID 0000-0002-4119-2606
Débora R SobreiraDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-2232-3922
Ittai EresDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-0265-8194
Dylan SosaDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-3162-0643
Jianhai ChenDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-0093-2003
Li ZhangChinese Institute for Brain Research, Beijing, China.ORCID 0000-0002-0698-0754
Patrick ReillyDepartment of Anthropology, Yale University, New Haven, CT, USA.ORCID 0000-0003-3468-9769
Alexander GuzzettaDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-8809-7438
J J EmersonDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0001-9474-0891
Peter AndolfattoDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0003-3393-4574
Qi ZhouDepartment of Neuroscience and Developmental Biology, University of Vienna, Vienna, Austria.ORCID 0000-0002-7419-2047
Li ZhaoLaboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA.ORCID 0000-0001-6776-1996
Manyuan LongDepartment of Ecology and Evolution, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-6755-197X

Funding

PREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0M
The genetic and epigenetic mechanisms of phenotypic innovationhttps://apps.era.nih.gov/gm/reportCheckList.do?applicationID=9798249R35GM133780 · NIGMS · ROCKEFELLER UNIVERSITY · PI Li Zhao · 2019 to 2026
$3.5M
Parallel evolution at Na,K-ATPase: a model system for understanding constraints on the evolution of novel protein functions.R01GM115523 · NIGMS · PRINCETON UNIVERSITY · PI ANDOLFATTO, PETER · 2015 to 2024
$2.8M
Reference-quality Drosophila genome assemblies for evolutionary analysis of previously inaccessible genomic regionsR01GM116113 · NIGMS · UNIVERSITY OF ARIZONA · PI CLARK, ANDREW G, LONG, MANYUAN · 2016 to 2019
$2.3M
Structural variation population size and the evolution of genome complexityR01GM123303 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI EMERSON, JAMES JORDAN · 2017 to 2021
$1.5M
The origin, maintenance, and adaptive consequences of variation in genome structureR35GM153327 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI James Jordan Emerson · 2024 to 2026
$1.1M
Assessing the generality of sexual conflict in new gene evolution in DrosophilaF32GM146423 · NIGMS · UNIVERSITY OF CHICAGO · PI ARSALA, DEANNA · 2022 to 2024
$213k
NIGMS NIH HHS F32 GM146423NIGMS NIH HHS R01 GM115523NIGMS NIH HHS R01 GM116113NIGMS NIH HHS R01 GM123303NIGMS NIH HHS R35 GM133780NIGMS NIH HHS R35 GM153327NIGMS NIH HHS T32 GM007197
6 · The paper itself

Abstract

Previous evolutionary models of duplicate gene evolution have overlooked the pivotal role of genome architecture. Here, we show that proximity-based regulatory recruitment by distally duplicated genes is an efficient mechanism for modulating tissue-specific production of preexisting proteins. By leveraging genomic asymmetries, we performed a coexpression analysis on

Indexed as

Drosophila melanogasterEnhancer Elements, GeneticEvolution, MolecularAnimalsDrosophila ProteinsGene DuplicationGenes, DuplicateGenome, InsectDrosophila Proteins

Identifiers

PMID39693425
PMCPMC11654672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.