ArticlePLOS digital health2024
The feasibility of a visuo-cognitive training intervention using a mobile application and exercise with stroboscopic glasses in Parkinson's: Findings from a pilot randomised controlled trial.
Article in PLOS digital health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effect of combined motor and cognitive rehabilitation on motor performance in Parkinson's disease: a systematic review and meta-analysis.Journal of rehabilitation medicine · 2026Pooled it
- The Effects of Digital Health Interventions on Motor Symptoms, Nonmotor Symptoms, and Quality of Life in Patients With Parkinson Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is currently no pharmacological treatment for visuo-cognitive impairments in Parkinson's disease. Alternative strategies are needed to address these non-motor symptoms given their impact on quality of life. Novel technologies have potential to deliver multimodal rehabilitation of visuo-cognitive dysfunction, but more research is required to determine their feasibility in Parkinson's.
objectiveTo determine the feasibility and preliminary efficacy of a home-based, technological visuo-cognitive training (TVT) intervention using a mobile application and exercise with stroboscopic glasses compared to non-technological care in people with Parkinson's.
methodsThis 18-month, parallel, two-arm pilot trial took place between July 2021-December 2022. Participants were community-dwelling individuals with a diagnosis of Parkinson's, aged over 50 years. Participants were randomly allocated to one of two active four-week interventions, TVT (n = 20) or standard care (SC) (n = 20). A physiotherapist delivered 8 home visits over 4 weeks, lasting 45-60 mins. Participants were evaluated at baseline and then on completion of the intervention. Primary outcomes were feasibility of the study design and intervention (recruitment/retention, adherence, assessment time scale, equipment and safety). Exploratory outcomes included assessments of cognitive, visual, clinical and motor function. (Blinding of participants was not possible due to the nature of the intervention).
resultsThe recruitment rate was 60% (40/67), and the retention rate was 98% (39/40). Adherence to both arms of the intervention was high, with participants attending 98% of visits in the TVT group and 96% of visits in the SC group. 35% (9/20) of participants in the TVT group experienced mild symptoms associated with use of the stroboscopic glasses which included dizziness, queasiness and unsteadiness. There were minimal between group differences, with both interventions having positive effects on a variety of clinical, cognitive, and physical performance outcomes.
conclusionsOur findings suggest that home-based TVT with a physiotherapist is feasible in people with Parkinson's and could provide an alternative approach to addressing cognitive and motor dysfunction in this population. We make recommendations for future trials and invite ensuing studies to improve upon the design and utilise stroboscopic visual training and digital tools to investigate this emerging area of multimodal rehabilitation. This trial was prospectively registered at ISRCTN (registration number: ISRCTN46164906; https://doi.org/10.1186/ISRCTN46164906).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.